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Titolo:
Catecholamine-induced vasoconstriction is sensitive to carbonic anhydrase I activation
Autore:
Puscas, I; Coltau, M; Gilau, L; Pasca, R; Domuta, G; Baican, M; Hecht, A;
Indirizzi:
Romanian Med Acad, Ctr Res & Med Assistance, Simleu Silvaniei 4775, Salaj,Romania Romanian Med Acad Simleu Silvaniei Salaj Romania 4775 4775, Salaj,Romania Med Care Unit, Staten Isl, NY USA Med Care Unit Staten Isl NY USAMed Care Unit, Staten Isl, NY USA Klin Wilkenberg, Wilkenberg, Germany Klin Wilkenberg Wilkenberg GermanyKlin Wilkenberg, Wilkenberg, Germany Fac Med, Oradea, Romania Fac Med Oradea RomaniaFac Med, Oradea, Romania
Titolo Testata:
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
fascicolo: 3, volume: 34, anno: 2001,
pagine: 339 - 345
SICI:
0100-879X(200103)34:3<339:CVISTC>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; INTRACELLULAR PH; SODIUM; ADRENOCEPTORS; LYMPHOCYTES; INHIBITION; MECHANISM; MEMBRANE; RECEPTOR;
Keywords:
adrenergic agonists; carbonic anhydrase; arterial blood pressure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Puscas, I Romanian Med Acad, Ctr Res & Med Assistance, 37 Dunarii St, Simleu Silvaniei 4775, Salaj, Romania Romanian Med Acad 37 Dunarii St Simleu Silvaniei Salaj Romania 4775
Citazione:
I. Puscas et al., "Catecholamine-induced vasoconstriction is sensitive to carbonic anhydrase I activation", BRAZ J MED, 34(3), 2001, pp. 339-345

Abstract

We studied the relationship between alpha- and beta-adrenergic agonists and the activity of carbonic anhydrase I and II in erythrocyte, clinical and vessel studies. Kinetic studies were performed. Adrenergic agonists increased erythrocyte carbonic anhydrase as follows: adrenaline by 75%, noradrenaline by 68%, isoprenaline by 55%, and orciprenaline by 62%. The kinetic dataindicated a non-competitive mechanism of action. In clinical studies carbonic anhydrase I from erythrocytes increased by 87% after noradrenaline administration, by 71% after orciprenaline and by 82% after isoprenaline. The increase in carbonic anhydrase I paralleled the increase in blood pressure. Similar results were obtained in vessel studies on piglet vascular smooth muscle. We believe that adrenergic agonists may have a dual mechanism of action: the first one consists of a catecholamine action on its receptor with the formation of a stimulus-receptor complex. The second mechanism proposedcompletes the first one. By this second component of the mechanism, the same stimulus directly acts on the carbonic anhydrase I isozyme (that might be functionally coupled with adrenergic receptors), so that its activation ensures an adequate pH for stimulus-receptor coupling for signal transduction into the cell, resulting in vasoconstriction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 09:36:48