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Titolo:
Expression of bone morphogenetic protein-6 and transforming growth factor-beta 1 in the rat brain after a mild and reversible ischemic damage
Autore:
Martinez, G; Carnazzaa, ML; Di Giacomo, C; Sorrenti, V; Vanella, A;
Indirizzi:
Univ Catania, Dept Anat Diagnost Pathol Legal Med & Publ Hlth G, I-95124 Catania, Italy Univ Catania Catania Italy I-95124 & Publ Hlth G, I-95124 Catania, Italy Univ Catania, Dept Biochem Med Chem & Mol Biol, Catania, Italy Univ Catania Catania Italy Biochem Med Chem & Mol Biol, Catania, Italy
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 894, anno: 2001,
pagine: 1 - 11
SICI:
0006-8993(20010309)894:1<1:EOBMPA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-BETA; HIPPOCAMPAL-NEURONS; CEREBRAL-ISCHEMIA; CORTICAL-NEURONS; GROWTH-FACTOR-BETA-1; HOMEOSTASIS; RECEPTORS; DEATH;
Keywords:
bone morphogenetic protein-6; transforming growth faster-beta 1; brain postischemic reperfusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Martinez, G Univ Catania, Dept Anat Diagnost Pathol Legal Med & Publ Hlth G, Via Biblioteca 4, I-95124 Catania, Italy Univ Catania Via Biblioteca 4 Catania Italy I-95124 ia, Italy
Citazione:
G. Martinez et al., "Expression of bone morphogenetic protein-6 and transforming growth factor-beta 1 in the rat brain after a mild and reversible ischemic damage", BRAIN RES, 894(1), 2001, pp. 1-11

Abstract

We have examined the distribution of transforming growth factor-beta1 (TGF-beta1) and bone morphogenetic protein-6 (BMP-6) in the brain of rats subjected to a mild and reversible ischemic damage produced by a 20-min occlusion of both carotid arteries without occlusion of the vertebral arteries. We have selected this model to study how the expression of trophic factor of the TGF-beta superfamily changes in neurons that recover from a transient insult. Immunocytochemical analysis showed a loss of TGF-beta1 in neurons of all hippocampal subfields immediately after the ischemic period, followed by a recovery of immunoreactivity in CAI and CA3 neurons after reperfusion. BMP-6 immunoreactivity was also lost in most hippocampal neurons, but immunostaining became particularly intense in the interstitial spare after both ischemia and reperfusion. An interstitial localization of BMP-6 was also observed in the cerebral cortex, particularly after reperfusion, Mild ischemia also induced substantial changes in the expression of TGF-beta1 and BMP-6within the cerebellar cortex. In control animals, these factors appeared to be localized in granule cells (TGF-beta1) and Purkinje cells (both), whereas the molecular layer was not immunopositive. Both TGF-beta1 and BMP-6 were highly expressed in the interstitial spaces of the cerebellar cortex either 20 min after ischemia or 20 min after reperfusion. Taken collectively, these results suggest that a mild and reversible ischemia stimulates the release of BMP-6 from neurons into the interstitial space. We speculate that BMP-B, besides functioning during brain development, may also regulate neuronal resistance to insults of the adult br ain. (C) 2001 Elsevier Science B. V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 21:44:09