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Titolo:
Anticholinergicity and cognitive processing in chronic schizophrenia
Autore:
Tracy, JI; Monaco, C; Giovannetti, T; Abraham, G; Josiassen, RC;
Indirizzi:
Thomas Jefferson Univ, Jefferson Med Coll, Dept Neurol, Philadelphia, PA 19107 USA Thomas Jefferson Univ Philadelphia PA USA 19107 hiladelphia, PA 19107 USA Thomas Jefferson Univ, Jefferson Med Coll, Dept Radiol, Philadelphia, PA 19107 USA Thomas Jefferson Univ Philadelphia PA USA 19107 hiladelphia, PA 19107 USA Drexel Univ, New York, NY USA Drexel Univ New York NY USADrexel Univ, New York, NY USA Norristown State Hosp, Clin Res Ctr, Norristown, PA USA Norristown State Hosp Norristown PA USA Clin Res Ctr, Norristown, PA USA
Titolo Testata:
BIOLOGICAL PSYCHOLOGY
fascicolo: 1, volume: 56, anno: 2001,
pagine: 1 - 22
SICI:
0301-0511(200103)56:1<1:AACPIC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONTINUOUS PERFORMANCE-TEST; HEALTHY-YOUNG VOLUNTEERS; STROOP TASK-PERFORMANCE; IDENTICAL PAIRS VERSION; SERUM LEVELS; SELECTIVE ATTENTION; DEPRESSED-PATIENTS; WORKING MEMORY; SYSTEMS; ACETYLCHOLINE;
Keywords:
acetylcholine; anticholinergic; schizophrenia; cognition; effortful and automatic processing; attention; autonomic arousal;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
83
Recensione:
Indirizzi per estratti:
Indirizzo: Tracy, JI Thomas Jefferson Univ, Jefferson Med Coll, Dept Neurol, Gibbon Bldg,Suite 4150,111 S 11th St, Philadelphia, PA 19107 USA Thomas Jefferson Univ Gibbon Bldg,Suite 4150,111 S 11th St Philadelphia PA USA 19107
Citazione:
J.I. Tracy et al., "Anticholinergicity and cognitive processing in chronic schizophrenia", BIOL PSYCH, 56(1), 2001, pp. 1-22

Abstract

Patients with chronic schizophrenia suffer from alterations in cholinergicfunctioning due to several factors, including the disease diathesis and pharmacologic treatments. Acetylcholine-cognition relationships are well explored in normals but are unclear in schizophrenia. Prior work indicated serum anticholinergicity does not cause global cognitive impairment in this group (Tracy et al., 1998a), raising the possibility that anticholinergicity normalizes an abnormal hyperactive cholinergic state. Serum anticholinergic levels were determined in 38 chronic schizophrenia patients using an established radioreceptor assay method. Six cognitive functions associated with cholinergic tone in normals were tested. The potential role of autonomic arousal and cigarette smoking were also assessed as both have been linked to cholinergic functioning. Regression analyses showed measures of inhibitory executive control and effortful memory accounted for a greater proportion ofthe Variance in the anticholinergicity measure compared to the other variables. The data demonstrate a relationship between high anticholinergicity and worse performance on two types of attention-resource demanding cognitiveprocesses and do not support the notion that reduced cholinergic tone normalizes a hyperactive cortical acetylcholine substrate. Relevant neuroanatomic structures and implications for models of cognitive deficits in schizophrenia are discussed. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 18/01/20 alle ore 22:13:32