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Titolo:
Clinical outcomes following cocaine infusion in nontreatment-seeking individuals with cocaine dependence
Autore:
Elman, I; Krause, S; Karlsgodt, K; Schoenfeld, DA; Gollub, RL; Breiter, HC; Gastfriend, DR;
Indirizzi:
Harvard Univ, Massachusetts Gen Hosp, Sch Med, Addict Res Program,Dept Psychiat, Boston, MA 02114 USA Harvard Univ Boston MA USA 02114 gram,Dept Psychiat, Boston, MA 02114 USA Harvard Univ, Sch Med, Boston, MA USA Harvard Univ Boston MA USAHarvard Univ, Sch Med, Boston, MA USA Massachusetts Gen Hosp, Motivat & Emot Neurosci Ctr, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 osci Ctr, Boston, MA 02114 USA Massachusetts Gen Hosp, Biostat Program, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Program, Boston, MA 02114 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 6, volume: 49, anno: 2001,
pagine: 553 - 555
SICI:
0006-3223(20010315)49:6<553:COFCII>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISSUES; ABUSE;
Keywords:
Addiction Severity Index; depression; radioimmunoassay of hair; cocaine; research ethics; brain imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Elman, I Harvard Univ, Massachusetts Gen Hosp, Sch Med, Addict Res Program,Dept Psychiat, 15 Parkman St,WACC-812, Boston, MA 02114 USA Harvard Univ 15 Parkman St,WACC-812 Boston MA USA 02114 02114 USA
Citazione:
I. Elman et al., "Clinical outcomes following cocaine infusion in nontreatment-seeking individuals with cocaine dependence", BIOL PSYCHI, 49(6), 2001, pp. 553-555

Abstract

Background: In this study we explored if laboratory-based cocaine administration to human subjects was associated with long-term adverse outcomes. Methods: Twenty-one non-treatment seeking individuals with cocaine dependence were evaluated at baseline and again 5 and 10 months following cocaine infusion in a brain imaging study. Outcomes included computer-driven multidimensional clinical assessments and radioimmuno-assay of hair For comparison, identical data were collected from 19 cocaine-dependent subjects who didnot receive the infusion. Results: The infused and noninfused groups did not differ on frequency of cocaine use (corroborated by radioimmunoassay of hair), Addiction Severity Index drug composite score, or Hamilton Rating Scale for Depression score at both follow-lip time points. In a time-related trend analysis, both groups showed significant reductions in frequency of cocaine use. Conclusions: Laboratory-based cocaine administration can be a safe paradigm even in individuals who are not engaged in treatment, Biol Psychiatry 2001;49:553-555 (C) 2001 Society of Biological Psychiatry.

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Documento generato il 04/04/20 alle ore 12:18:10