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Titolo:
A quantitative MRI study of posterior fossa development in velocardiofacial syndrome
Autore:
Eliez, S; Schmitt, JE; White, CD; Wellis, VG; Reiss, AL;
Indirizzi:
Stanford Univ, Dept Psychiat & Behav Sci, Sch Med, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 Sci, Sch Med, Stanford, CA 94305 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 6, volume: 49, anno: 2001,
pagine: 540 - 546
SICI:
0006-3223(20010315)49:6<540:AQMSOP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIO-FACIAL SYNDROME; CHILDHOOD-ONSET SCHIZOPHRENIA; 22Q11 DELETION SYNDROME; GOOSECOID-LIKE GSCL; FRAGILE-X-SYNDROME; CEREBELLAR VERMIS; DIGEORGE-SYNDROME; WILLIAMS SYNDROME; JOUBERT-SYNDROME; BRAIN ANOMALIES;
Keywords:
velocardiofacial; VCFS; 22q11.2; brain; MRI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Eliez, S Stanford Univ, Dept Psychiat & Behav Sci, Sch Med, 401 Quarry Rd,Stanford, CA 94305 USA Stanford Univ 401 Quarry Rd Stanford CA USA 94305 d, CA 94305 USA
Citazione:
S. Eliez et al., "A quantitative MRI study of posterior fossa development in velocardiofacial syndrome", BIOL PSYCHI, 49(6), 2001, pp. 540-546

Abstract

Background: Velocardiofacial syndrome (VCFS) has been identified as a riskfactor for developing schizophrenia. Qualitative neuroimaging studies indicated that VCFS was frequently associated with abnormal development of structures in the posterior fossa of the brain. The objective of this investigation was to identify the specific structures affected in the posterior fossa and investigate the association of these neuroanatomic variations with behaviors potentially related to later-onset psychiatric disorders. Methods: Twenty-four children and adolescents with VCFS individually matched for age and gender with 24 control subjects received magnetic resonance imaging scans. Analysis of covariance models were used to investigate regional brain differences. Association between brain areas and behaviors measured on the Child Behavior Checklist (CBCL) were assessed using simple regression models. Results: Children with VCFS had significantly smaller size of vermal lobules VI-VII and the pens after adjusting for overall brain size. There were no significant associations between scores on the CBCL and measures of neuroanatomic variation within the VCFS group. Conclusions: Structural alterations of the posterior fossa in VCFS are specifically limited to cerebellar vermis lobules VI-VII and pens. Previous literature has suggested that the vermis is involved in social cognition, andalteration of lobules VI-VII could therefore partially explain the neurobehavioral profile associated with VCFS. Biol Psychiatry 2001;49:540-546 (C) 2001 Society of Biological Psychiatry.

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Documento generato il 05/04/20 alle ore 19:30:21