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Titolo:
Differential expression of signal transducers and activators of transcription during human adipogenesis
Autore:
Harp, JB; Franklin, D; Vanderpuije, AA; Gimble, JM;
Indirizzi:
Univ N Carolina, Dept Nutr, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 Nutr, Chapel Hill, NC 27599 USA Zen Bio Inc, Res Triangle Pk, NC USA Zen Bio Inc Res Triangle Pk NC USAZen Bio Inc, Res Triangle Pk, NC USA
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 4, volume: 281, anno: 2001,
pagine: 907 - 912
SICI:
0006-291X(20010309)281:4<907:DEOSTA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADIPOCYTE PRECURSOR CELLS; GENE-EXPRESSION; PPAR-GAMMA; STAT5B; ALPHA;
Keywords:
STAT; preadipocytes; adipocytes; adipogenesis; peroxisome proliferator-activated receptor; CCAAT/enhancer binding proteins; and transcription factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Harp, JB Univ N Carolina, Dept Nutr, CB 7400 McGavran Greenberg Hall, Chapel Hill, NC 27599 USA Univ N Carolina CB 7400 McGavran Greenberg Hall Chapel Hill NC USA 27599
Citazione:
J.B. Harp et al., "Differential expression of signal transducers and activators of transcription during human adipogenesis", BIOC BIOP R, 281(4), 2001, pp. 907-912

Abstract

Signal Transducers and Activators of Transcription (STATs) display unique expression patterns upon induction of differentiation of murine 3T3-L1 preadipocytes into adipocytes. During differentiation, expression of STAT1 and STATE increase, while STAT3 and STAT6 remain relatively unchanged. Here, wedetermined whether human subcutaneous preadipocytes expressed STATs and ifthe pattern of expression changed during adipogenesis. We found by Westernblot analysis that freshly isolated preadipocytes expressed STAT1, STAT3, STATE, and STAT6, but not STAT2 and STAT4. Induction of preadipocyte differentiation with 1-methyl-3-isobutylxanthine, dexamethasone, insulin, and BRL49653 decreased expression of STAT1, and increased expression of STAT3 and STATE. STAT6 expression did not change during adipogenesis. Changes in expression of CCAAT/enhancer binding protein beta (C/EBP beta), C/EBP delta, C/EBP alpha, and peroxisome proliferator-activated receptor gamma were similar to murine cell lines. These results suggest that unlike the traditional adipogenic transcription factors, unique differences exist in STAT expression patterns between murine and human adipose cells, (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 12:57:04