Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Depletion of cholinergic neurons of the medullary arcuate nucleus in multiple system atrophy
Autore:
Benarroch, EE; Schmeichel, AM; Parisi, JE;
Indirizzi:
Mayo Clin & Mayo Fdn, Dept Neurol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 urol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn, Dept Pathol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 thol, Rochester, MN 55905 USA
Titolo Testata:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
fascicolo: 2-3, volume: 87, anno: 2001,
pagine: 293 - 299
SICI:
1566-0702(20010323)87:2-3<293:DOCNOT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFANT-DEATH-SYNDROME; PARKINSONS-DISEASE; RECEPTOR-BINDING; CHEMORECEPTORS; SLEEP;
Keywords:
sleep apnea; chemosensitive area; choline-acetyltransferase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Benarroch, EE Mayo Clin & Mayo Fdn, Dept Neurol, 200 1St St Sw, Rochester,MN 55905 USA Mayo Clin & Mayo Fdn 200 1St St Sw Rochester MN USA 55905 SA
Citazione:
E.E. Benarroch et al., "Depletion of cholinergic neurons of the medullary arcuate nucleus in multiple system atrophy", AUTON NEURO, 87(2-3), 2001, pp. 293-299

Abstract

The human arcuate nucleus (ArcN) has been considered akin to the pontine precerebellar nuclei. However, there is anatomical, functional, and clinicalevidence that the ArcN may be the homologue of chemosensitive areas of theventral medullary surface involved in ventilatory responses to hypercarbiaand cerebrospinal fluid acidosis. Acetylcholine has been involved in mechanisms of central chemosensitivity. Loss of ArcN neurons has been reported in patients with multiple system atrophy (MSA), a disorder characterized by disturbed automatic ventilation, but the neurochemical identity of these neurons is undetermined. We sou ht to determine whether the ArcN contains cholinergic neurons and whether these neurons are depleted in patients with MSA. Medullae were obtained from six patients with MSA, five patients with Parkinson's disease (PD) and six sex- and age-matched controls. Fifty-micron transverse sections obtained through the mid-olivary levels were processed for acetylcholinesterase (AchE), choline acetyltransferase (CAT), and alpha-synuclein immunoreactivity. We found that the ArcN contained CAT-positiveneurons. There was a significant decrease in density of cholinergic ArcN neurons in MSA but not in PD patients, alpha -Synuclein-containing inclusions were present in the ArcN of MSA patients. Depletion of cholinergic neurons may provide a substrate for disturbances in automatic respiration in MSA patients. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:14:15