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Titolo:
Mechanical responses evoked by nerve stimulation in gastric muscles of mouse lacking inositol trisphosphate receptor
Autore:
Takano, H; Imaeda, K; Yamamoto, Y; Kato, K; Mikoshiba, K; Suzuki, H;
Indirizzi:
Nagoya City Univ, Sch Med, Dept Physiol, Mizuho Ku, Nagoya, Aichi 4678601,Japan Nagoya City Univ Nagoya Aichi Japan 4678601 , Nagoya, Aichi 4678601,Japan Japan Sci & Technol Corp, Exploratory Res Adv Technol, Physiol Sect, Bunkyo Ku, Tokyo 1130021, Japan Japan Sci & Technol Corp Tokyo Japan 1130021 yo Ku, Tokyo 1130021, Japan Univ Tokyo, Inst Med Sci, Dept Mol Neurol, Minato Ku, Tokyo 1088639, JapanUniv Tokyo Tokyo Japan 1088639 l Neurol, Minato Ku, Tokyo 1088639, Japan RIKEN, Inst Phys & Chem Res, Brain Sci Inst, Dev Neurobiol Lab, Wako, Saitama 3510106, Japan RIKEN Wako Saitama Japan 3510106 robiol Lab, Wako, Saitama 3510106, Japan
Titolo Testata:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
fascicolo: 2-3, volume: 87, anno: 2001,
pagine: 249 - 257
SICI:
1566-0702(20010323)87:2-3<249:MREBNS>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERSTITIAL-CELLS; SMOOTH-MUSCLE; INHIBITORY NEUROTRANSMISSION; JUNCTION POTENTIALS; NITRIC-OXIDE; CAJAL; CHANNELS; STOMACH; MICE;
Keywords:
gastric smooth muscle; cholinergic excitation; adrenergic inhibition; nitroxidergic inhibition; NANC inhibition; substance P;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, H Nagoya City Univ, Sch Med, Dept Physiol, Mizuho Ku, Nagoya, Aichi 4678601,Japan Nagoya City Univ Nagoya Aichi Japan 4678601 Aichi 4678601,Japan
Citazione:
H. Takano et al., "Mechanical responses evoked by nerve stimulation in gastric muscles of mouse lacking inositol trisphosphate receptor", AUTON NEURO, 87(2-3), 2001, pp. 249-257

Abstract

Alteration of mechanical responses elicited by transmural nerve stimulation (TNS) was investigated in pylorus muscle of stomach isolated from mutant mice lacking expression of IP3 type-1 receptor. In wild and mutant mice, TNS inhibited spontaneous contractions and generated an off-response at the cessation. The effects of inhibitors of neurotransmission revealed that in wild mice, acetylcholine and nitric oxide were involved as excitatory and inhibitory mediators, respectively. In mutant mice, a lack of nitroxidergic component with associated attenuation of cholinergic transmission was found. The off-response was inhibited by apamin in both mice. In mutant mice, spantide-sensitive excitatory response appeared in the presence of apamin. Acetylcholine and substance P enhanced while noradrenaline and sodium nitroprusside inhibited spontaneous contractions, in both wild and mutant mice; theactions were weaker in mutant mice than in wild mice for any agonists. Theresults indicate that pylorus smooth muscles receive cholinergic excitatory and nitroxidergic and non-adrenergic non-cholinergic inhibitory projections, and a lack of IP3 type-1 receptor results in an impairment of cholinergic and nitroxidergic components, with no alteration of non-adrenergic non-cholinergic inhibitory projections. In addition, the mutation induces a substance P projection which is not detected in wild mice. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 06/04/20 alle ore 05:36:35