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Titolo:
Increased levels of hypothalamic neuronal nitric oxide synthase and vasopressin in salt-loaded Dahl rat
Autore:
Serino, R; Ueta, Y; Hanamiya, M; Nomura, M; Yamamoto, Y; Yamaguchi, K; Nakashima, Y; Yamashita, H;
Indirizzi:
Univ Occupat & Environm Hlth, Dept Physiol, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555 8555, Japan Univ Occupat & Environm Hlth, Sch Med, Dept Internal Med 2, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan8078555 8555, Japan Niigata Univ, Sch Med, Dept Physiol, Niigata 9518510, Japan Niigata Univ Niigata Japan 9518510 Dept Physiol, Niigata 9518510, Japan
Titolo Testata:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
fascicolo: 2-3, volume: 87, anno: 2001,
pagine: 225 - 235
SICI:
1566-0702(20010323)87:2-3<225:ILOHNN>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NOS GENE-EXPRESSION; SUPRAOPTIC NUCLEI; MAGNOCELLULAR NEURONS; BLOOD-PRESSURE; SENSITIVE RATS; PARAVENTRICULAR NUCLEUS; ARGININE-VASOPRESSIN; INDUCED HYPERTENSION; WATER-DEPRIVATION; NADPH-DIAPHORASE;
Keywords:
arginine vasopressin; Dahl; hypertension; nitric oxide; oxytocin; salt;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Ueta, Y Univ Occupat & Environm Hlth, Dept Physiol, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555pan
Citazione:
R. Serino et al., "Increased levels of hypothalamic neuronal nitric oxide synthase and vasopressin in salt-loaded Dahl rat", AUTON NEURO, 87(2-3), 2001, pp. 225-235

Abstract

The plasma concentration of arginine vasopression (AVP) and the expressionlevel of the neuronal nitric oxide synthase (nNOS) gene in the paraventricular nucleus (PVN) and the supraoptic nucleus (SON) of Sprague-Dawley (SD),Dahl salt-sensitive (S) and Dahl salt-resistant (R) rats on a high salt diet were examined by radioimmunoassay for AVP and in situ hybridization histochemistry for nNOS. The high salt diet containing 8.0% NaCl was given for 4 weeks. The concentrations of AVP in hypertensive Dahl S rats were significantly increased in comparison with those in SD rats and Dahl R rats on a high salt diet. The levels of nNOS mRNA and NADPH-diaphorase activity in thePVN and SON of hypertensive Dahl S rats were greater than those in Dahl R rats on a high salt diet. The antihypertensive drugs, either nicardipine orcaptopril were administered to the Dahl S rats for 2 weeks beginning 2 weeks after the start of the high salt diet. The nNOS mRNA in the PVN and SON of Dahl S rats given a high salt diet was not upregulated by treatment withnicardipine, while the nNOS mRNA in salt-loaded Dahl S rats was greater upregulated by treatment with captopril to that greater than without the antihypertensive drug. Our results suggest that the increased NO production in the PVN and SON of hypertensive Dahl S rats may be ineffective in decreasing blood pressure or inhibiting AVP secretion. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:48:42