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Titolo:
Effects of ketamine and propofol on autonomic cardiovascular function in chronically instrumented rats
Autore:
Akine, A; Suzuka, H; Hayashida, Y; Kato, Y;
Indirizzi:
Nagasaki Univ, Sch Dent, Dept Dent Pharmacol, Nagasaki 8528588, Japan Nagasaki Univ Nagasaki Japan 8528588 Pharmacol, Nagasaki 8528588, Japan Univ Occupat & Environm Hlth, Dept Syst Physiol, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555 8555, Japan
Titolo Testata:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
fascicolo: 2-3, volume: 87, anno: 2001,
pagine: 201 - 208
SICI:
1566-0702(20010323)87:2-3<201:EOKAPO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC-NERVE ACTIVITY; BARORECEPTOR REFLEX; HEART-RATE; RABBITS; ATTENUATION; ISOFLURANE; ANESTHESIA;
Keywords:
ketamine; propofol; renal sympathetic nerve activity; chronically instrumented rats; baroreflex sensitivity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Akine, A Nagasaki Univ, Sch Dent, Dept Dent Pharmacol, 1-7-1 Sakamoto, Nagasaki 8528588, Japan Nagasaki Univ 1-7-1 Sakamoto Nagasaki Japan 8528588 28588, Japan
Citazione:
A. Akine et al., "Effects of ketamine and propofol on autonomic cardiovascular function in chronically instrumented rats", AUTON NEURO, 87(2-3), 2001, pp. 201-208

Abstract

In this study, we systematically examined the effects of ketamine and propofol at various doses (5-20 mg/kg) on blood pressure, heart rate and renal sympathetic nerve activity in chronically instrumented Wistar rats. We alsoassessed the effects of these anesthetics on the baroreflex control of heart rate and renal sympathetic nerve activity. Ketamine (10 mg/kg) increasedblood pressure by 30.0+/-4.5%, heart rate by 17.7+/-3.3% and renal sympathetic nerve activity by 38.8+/-14.6%, while propofol (10 mg/kg) decreased blood pressure by 18.9+/-3.5%, heart rate by 5.5+/-2.5% and renal sympatheticnerve activity by 7.5+/-2.1%. These variables showed dose-dependent responses to both agents. Both ketamine and propofol decreased the range and maximum gain of the logistic function curve obtained by relating mean blood pressure to heart rate and blood pressure to renal sympathetic nerve activity. In conclusion, ketamine and propofol had different effects on autonomic cardiovascular function, but attenuated the baroreflex sensitivity of heart rate and renal sympathetic nerve activity in a dose-dependent manner. These results suggest the possibility that baroreflex sensitivity may reflect thedepth of anesthesia. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 06/04/20 alle ore 19:09:14