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Titolo:
Familial clustering of high factor VIII levels in patients with venous thromboembolism
Autore:
Schambeck, CM; Hinney, K; Haubitz, I; Taleghani, BM; Wahler, D; Keller, F;
Indirizzi:
Univ Wurzburg, Med Klin, Zent Lab, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 nt Lab, D-97080 Wurzburg, Germany Univ Wurzburg, Dept Med, Blood Coagulat Unit, Wurzburg, Germany Univ Wurzburg Wurzburg Germany , Blood Coagulat Unit, Wurzburg, Germany Univ Wurzburg, Ctr Comp, Wurzburg, Germany Univ Wurzburg Wurzburg Germany iv Wurzburg, Ctr Comp, Wurzburg, Germany Univ Wurzburg, Dept Transfus Med, Wurzburg, Germany Univ Wurzburg Wurzburg Germany rg, Dept Transfus Med, Wurzburg, Germany
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 2, volume: 21, anno: 2001,
pagine: 289 - 292
SICI:
1079-5642(200102)21:2<289:FCOHFV>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
VON-WILLEBRAND-FACTOR; ACTIVATED PROTEIN-C; MAMMALIAN-CELLS; FACTOR-V; THROMBOSIS; SECRETION; THROMBOPHILIA; REGION; GENE;
Keywords:
factor VIII; inherited thrombophilia; familial thrombosis; venous thromboembolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Schambeck, CM Univ Wurzburg, Med Klin, Zent Lab, Josef Schneider Str 2, D-97080 Wurzburg, Germany Univ Wurzburg Josef Schneider Str 2 Wurzburg Germany D-97080
Citazione:
C.M. Schambeck et al., "Familial clustering of high factor VIII levels in patients with venous thromboembolism", ART THROM V, 21(2), 2001, pp. 289-292

Abstract

High levels of factor VIII (FVIII) but not von Willebrand factor (vWF) areknown to increase the risk for venous thromboembolism, Whether high FVIII levels originate from hereditary defects or from acquired conditions remains unanswered. The objective of our study was to investigate whether there is evidence for familial clustering of elevated FVIII levels in families in which greater than or equal to1 member has been affected by a thromboembolic event and had reproducibly high FVIII levels. We investigated FVIII levels in 361 patients with previous venous thromboembolism. FVIII levels were measured by a chromogenic assay; the cutoff value was defined as the 98th percentile of FVIII plasma levels of 266 blood donors. vWF levels were determined by an enzyme immunoassay. After exclusion of known causes of FVIII elevation, such as the acute thrombotic event itself; inflammation; malignancy; liver, renal, or vascular disease; surgery; or pregnancy, we included 17 patients with unexplained, reproducibly high FVIII levels. The investigation was also extended to these patients' relatives. Multiple regressive analysis of blood donors and asymptomatic family members showed that the affiliation with a family in which 1 member suffered from venous thromboembolism and had reproducibly high FVIII levels is the second most important predictor for FVIII levels. Familial clustering was analyzed by the Houwing-Duistermaat familial aggregation test. After adjustment for the influence of age, sex, blood group, and vWF, FVIII levels were significantly (P=0.038) clustered within families. In conclusion, FVIII levels seem to be familially determined in families in which a member showed high FVIII levels after previous venous thromboembolism.

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Documento generato il 15/08/20 alle ore 18:53:55