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Titolo:
Metabolic and lifestyle determinants of postprandial lipemia differ from those of fasting triglycerides - The Atherosclerosis Risk in Communities (ARIC) study
Autore:
Sharrett, AR; Heiss, G; Chambless, LE; Boerwinkle, E; Coady, SA; Folsom, AR; Patsch, W;
Indirizzi:
NHLBI, Div Epidemiol & Clin Applicat, Epidemiol & Biometry Program, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892 ol & Biometry Program, Bethesda, MD 20892 USA Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA Univ NCarolina Chapel Hill NC USA , Dept Epidemiol, Chapel Hill, NC USA Univ N Carolina, Sch Publ Hlth, Dept Biostat, Chapel Hill, NC USA Univ N Carolina Chapel Hill NC USA th, Dept Biostat, Chapel Hill, NC USA Univ Texas, Hlth Sci Ctr, Genet Ctr, Houston, TX USA Univ Texas Houston TX USA exas, Hlth Sci Ctr, Genet Ctr, Houston, TX USA Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 demiol, Minneapolis, MN 55455 USA Landeskrankenanstalten, Dept Lab Med, Salzburg, Austria Landeskrankenanstalten Salzburg Austria Dept Lab Med, Salzburg, Austria
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 2, volume: 21, anno: 2001,
pagine: 275 - 281
SICI:
1079-5642(200102)21:2<275:MALDOP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
MIDDLE-AGED MEN; HIGH-DENSITY-LIPOPROTEIN; CORONARY-ARTERY DISEASE; RETINYL PALMITATE RESPONSES; CIGARETTE-SMOKING; PHYSICAL-ACTIVITY; ALCOHOL; WOMEN; ASSOCIATION; CLEARANCE;
Keywords:
lipoproteins; postprandial; chylomicrons;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Sharrett, AR NHLBI, Div Epidemiol & Clin Applicat, Epidemiol & Biometry Program, Room 8164,MSC 7934,6701 Rockledge Dr, Bethesda, MD 20892 USA NHLBI Room 8164,MSC 7934,6701 Rockledge Dr Bethesda MD USA 20892
Citazione:
A.R. Sharrett et al., "Metabolic and lifestyle determinants of postprandial lipemia differ from those of fasting triglycerides - The Atherosclerosis Risk in Communities (ARIC) study", ART THROM V, 21(2), 2001, pp. 275-281

Abstract

Despite the reported association of lipoprotein responses to a fatty meal with atherosclerosis, little is known about the determinants of these responses. Plasma triglyceride, retinyl palmitate, and apolipoprotein B-48 responses to a standardized fatty meal containing a vitamin A marker were measured in 602 Atherosclerosis Risk in Communities (ARIC) study participants. Tofocus on postprandial responses specifically, which have been reported to be related to atherosclerosis independently of fasting triglycerides, analyses for determinants of postprandial responses were adjusted for fasting triglycerides. Major determinants of fasting triglycerides, namely, diabetes,obesity, other factors related to insulin resistance, and male sex, were not independently associated with postprandial responses. Fasting triglycerides were the strongest predictor of postprandial lipids, but independent oftriglycerides, the predictors of postprandial responses were smoking, diet, creatinine, and alcohol, Smokers had substantially increased retinyl palmitate and apolipoprotein B-48 responses, indicators of chylomicrons and their remnants. Persons who consume more calories or omega3 fatty acids had reduced chylomicron responses, Triglyceride responses were associated positively with serum creatinine levels and negatively with moderate alcohol consumption. Thus, determinants of fasting and postprandial lipids differ. The independent atherogenic influence of postprandial lipids may relate more to smoking and diet than to obesity and insulin resistance.

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Documento generato il 10/04/20 alle ore 02:39:58