Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Cellular senescence after single and repeated balloon catheter denudationsof rabbit carotid arteries
Autore:
Fenton, M; Barker, S; Kurz, DJ; Erusalimsky, JD;
Indirizzi:
Univ London Univ Coll, Rayne Inst, Dept Med, Ctr Cardiovasc Biol & Med,Cell Biol Grp, London WC1E 6JJ, England Univ London Univ Coll London EnglandWC1E 6JJ , London WC1E 6JJ, England Univ Coll London, Royal Free & Univ Coll Med Sch, Dept Surg, London, England Univ Coll London London England oll Med Sch, Dept Surg, London, England
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 2, volume: 21, anno: 2001,
pagine: 220 - 226
SICI:
1079-5642(200102)21:2<220:CSASAR>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; ENDOTHELIAL-CELLS; ATHEROSCLEROTIC PLAQUES; REPLICATIVE SENESCENCE; BETA-GALACTOSIDASE; TELOMERE LENGTH; HUMAN AORTA; IN-VIVO; APOPTOSIS; INJURY;
Keywords:
endothelial cells; vascular smooth muscle cells; senescence; beta-galactosidase; neointima;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Erusalimsky, JD Univ London Univ Coll, Rayne Inst, Dept Med, Ctr Cardiovasc Biol & Med,Cell Biol Grp, Ground Floor,Room G15,5 Univ St, London WC1E 6JJ, England Univ London Univ Coll Ground Floor,Room G15,5 Univ St London England WC1E 6JJ
Citazione:
M. Fenton et al., "Cellular senescence after single and repeated balloon catheter denudationsof rabbit carotid arteries", ART THROM V, 21(2), 2001, pp. 220-226

Abstract

The hypothesis that increased cellular proliferation in the vasculature may lead to replicative senescence has been tested in a model of neointima formation. We have used a biomarker of replicative senescence, senescence-associated beta -galactosidase (SA-beta -gal), to detect senescence in rabbit carotid arteries subjected to single and double balloon denudations. We found an accumulation of senescent cells in the neointima and media of all injured vessels, in contrast to the near absence of such cells in control vessels. The relative area occupied by SA-beta -gal-positive cells was higher in vessels subjected to double denudation than in those subjected to single denudation, both in the neointima (0.99% versus 0.06%, respectively; P<0.001) and in the media (0.11% versus 0.01%, respectively; P<0.02), The majority of SA-beta -gal-positive cells were vascular smooth muscle cells, and a minority were endothelial cells. SA-beta -gal-positive cells showed no evidence of apoptosis by use of terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling. Our results indicate that the proliferative responsethat follows intraluminal injury to the artery leads to the emergence of senescent endothelial and smooth muscle cells. The demonstration that vascular cell senescence can occur in vivo suggests that this process may be involved in cardiovascular pathologies that have a proliferative component.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 01:47:33