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Titolo:
Does therapeutic intervention achieve slowing of progression or bona fide regression of atherosclerotic lesions?
Autore:
Stein, Y; Stein, O;
Indirizzi:
Hadassah Univ Hosp, Div Med, Lipid Res Lab, IL-91120 Jerusalem, Israel Hadassah Univ Hosp Jerusalem Israel IL-91120 IL-91120 Jerusalem, Israel
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 2, volume: 21, anno: 2001,
pagine: 183 - 188
SICI:
1079-5642(200102)21:2<183:DTIASO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; APOLIPOPROTEIN-A-I; CHOLESTEROL-FED RABBITS; CORONARY-ARTERY DISEASE; DIRECTED GENE-TRANSFER; APOE-DEFICIENT MICE; HMG-COA REDUCTASE; LDL-APHERESIS; FAMILIAL HYPERCHOLESTEROLEMIA; TRANSGENIC MICE;
Keywords:
atherosclerosis; prevention of CAD; fatty streaks; complex lesion; gene therapy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Stein, Y Hadassah Univ Hosp, Div Med, Lipid Res Lab, POB 12220, IL-91120 Jerusalem,Israel Hadassah Univ Hosp POB 12220 Jerusalem Israel IL-91120 em,Israel
Citazione:
Y. Stein e O. Stein, "Does therapeutic intervention achieve slowing of progression or bona fide regression of atherosclerotic lesions?", ART THROM V, 21(2), 2001, pp. 183-188

Abstract

This review focuses on the regression of atherosclerosis in humans and experimental animals. It highlights the difficulties to determine unequivocally whether with a given therapeutic intervention, such as diet, drugs, or apheresis, the progression of lesions was curtailed or bona fide regression of atherosclerotic lesions was achieved. It seems appropriate to mention that 2 very different ways to measure regression were used in experimental animals and in humans. Regression in animals was determined mainly in the aorta or coronary arteries isolated at post mortem, and the criteria used were degree of sudanophilia and/or aortic wall thickness and cellular composition or cholesterol content. In humans, the evaluation of regression relied mainly on quantitative coronary angiography. The literature of the past decade is reviewed selectively but not exhaustively, and in some instances, a brief historical overview is given.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 14:34:20