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Titolo:
Natural history and topographic pattern of progression of coronary calcification in symptomatic patients - An electron-beam CT study
Autore:
Schmermund, A; Baumgart, D; Mohlenkamp, S; Kriener, P; Pump, H; Gronemeyer, D; Seibel, R; Erbel, R;
Indirizzi:
Univ Clin Essen, Dept Cardiol, D-45122 Essen, Germany Univ Clin Essen Essen Germany D-45122 pt Cardiol, D-45122 Essen, Germany Inst MicroTherapy, Bochum, Germany Inst MicroTherapy Bochum GermanyInst MicroTherapy, Bochum, Germany Inst Diagnost & Intervent Radiol, Mulheim, Germany Inst Diagnost & Intervent Radiol Mulheim Germany diol, Mulheim, Germany Univ Witten Herdecke, Dept Radiol & MicroTherapy, Witten, Germany Univ Witten Herdecke Witten Germany iol & MicroTherapy, Witten, Germany
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 3, volume: 21, anno: 2001,
pagine: 421 - 426
SICI:
1079-5642(200103)21:3<421:NHATPO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ULTRAFAST COMPUTED-TOMOGRAPHY; ARTERY DISEASE; INTRACORONARY ULTRASOUND; CALCIUM; ATHEROSCLEROSIS; REPRODUCIBILITY; ANGIOGRAPHY; LESIONS; QUANTIFICATION;
Keywords:
progression; coronary atherosclerosis; calcium; electron-beam CT; coronary artery disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Schmermund, A Univ Clin Essen, Dept Cardiol, Hufelandstr 55, D-45122 Essen, Germany Univ Clin Essen Hufelandstr 55 Essen Germany D-45122 ermany
Citazione:
A. Schmermund et al., "Natural history and topographic pattern of progression of coronary calcification in symptomatic patients - An electron-beam CT study", ART THROM V, 21(3), 2001, pp. 421-426

Abstract

Electron-beam CT may assess the progression of coronary atherosclerosis byvisualizing changes in calcification. The present investigation analyzes (1) the rate of progression of calcification in symptomatic patients, (2) the topographic pattern, and (3) the influence of baseline plaque burden and risk factors. Progression of calcification during a mean (median) interval of 18 (15) months was measured in 102 symptomatic outpatients (aged 59+/-9 years, 80% male) with calcification. In 4 patient groups with a baseline total score (Agatston criteria) of 1 to 30, >30 to 100, >100 to 400, and >400, the median was 3.1, 26.1, 58.9, and 109.7, respectively, for absolute annual progression of the score (P<0.05) and 57%, 49%, 32%, and 15%, respectively, for relative progression (P<0.05). On the coronary segmental level, changes were largely restricted to typical predilection sites of coronary atherosclerosis. The presence of angiographically defined coronary narrowing influenced absolute, but not relative, progression. Of the risk factors, only low density lipoprotein cholesterol levels showed a trend, although not significant, for predicting progression. These data indicate that baseline plaque burden determines the rate of progression of calcification. This appears to be a coronary systemic process, reflecting the natural history of coronary atherosclerosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:52:27