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Titolo:
Effect of probucol in lecithin-cholesterol acyltransferase-deficient mice - Inhibition of 2 independent cellular cholesterol-releasing pathways in vivo
Autore:
Tomimoto, S; Tsujita, M; Okazaki, M; Usui, S; Tada, T; Fukutomi, T; Ito, S; Itoh, M; Yokoyama, S;
Indirizzi:
Nagoya City Univ, Sch Med, Dept Biochem 1, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ Nagoya Aichi Japan 4678601 Nagoya, Aichi 4678601, Japan Nagoya City Univ, Sch Med, Dept Internal Med 1, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ Nagoya Aichi Japan 4678601 Nagoya, Aichi 4678601, Japan Nagoya City Univ, Sch Nursing, Dept Pathol, Mizuho Ku, Nagoya, Aichi 4678601, Japan Nagoya City Univ Nagoya Aichi Japan 4678601 Nagoya, Aichi 4678601, Japan Tokyo Med & Dent Univ, Coll Liberal Arts & Sci, Chem Lab, Ichikawa, Japan Tokyo Med & Dent Univ Ichikawa Japan s & Sci, Chem Lab, Ichikawa, Japan Tokyo Med & Dent Univ, Sch Allied Hlth Sci, Tokyo, Japan Tokyo Med & Dent Univ Tokyo Japan iv, Sch Allied Hlth Sci, Tokyo, Japan
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 3, volume: 21, anno: 2001,
pagine: 394 - 400
SICI:
1079-5642(200103)21:3<394:EOPILA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; BINDING CASSETTE TRANSPORTER-1; APOLIPOPROTEIN-A-I; TANGIER-DISEASE; FAMILIAL HYPERCHOLESTEROLEMIA; ANIMAL-MODEL; LIPID EFFLUX; GENE; MACROPHAGES; ABC1;
Keywords:
high density lipoproteins; lecithin-cholesterol acyltransferase; cholesterol efflux; cholesterol homeostasis; probucol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Yokoyama, S Nagoya City Univ, Sch Med, Dept Biochem 1, Mizuho Ku, Kawasumi1,Mizuho Cho, Nagoya, Aichi 4678601, Japan Nagoya City Univ Kawasumi 1,Mizuho Cho Nagoya Aichi Japan 4678601
Citazione:
S. Tomimoto et al., "Effect of probucol in lecithin-cholesterol acyltransferase-deficient mice - Inhibition of 2 independent cellular cholesterol-releasing pathways in vivo", ART THROM V, 21(3), 2001, pp. 394-400

Abstract

Cellular cholesterol release takes place by at least 2 distinct mechanisms: the lecithin-cholesterol acyltransferase (LCAT)-driven net efflux by cholesterol diffusion and the generation of high density lipoprotein (HDL) withcellular cholesterol and phospholipid on the cell-apolipoprotein interaction. Therefore, LCAT deficiency impairs the former pathway, and the latter can be inhibited by probucol, which interferes with the apolipoprotein-cell interaction. Hence, probucol was given to the LCAT-deficient mice in the attempt to suppress both of these pathways. The mice were fed low (0.2%) and high (1.2%) cholesterol diets containing 0.5% probucol for 2 weeks. LCAT deficiency and probucol markedly decreased plasma HDL, and the effects were synergistic. Tissue cholesterol content was lower in the adrenal glands and ovaries in the LCAT-deficient mice and in the probucol-treated mice, suggesting that HDL is a main cholesterol provider for these organs. It was also moderately decreased in the spleen of the low cholesterol-fed female mice and in the thyroid gland of the low cholesterol-fed male mice. On the other hand, the esterified cholesterol content in the liver was substantially increased by the probucol treatment with a high cholesterol diet in the LCAT-deficient mice hut not in the wild-type mice. Among the groups, there was nosignificant difference in the tissue cholesterol levels in other organs, such as the liver, spleen, thymus, brain, erythrocytes, thyroid gland, testis, and aorta, resulting from either LCAT deficiency or probucol. Thus, the apolipoprotein-mediated mechanism plays a significant role in the export ofcellular cholesterol in the liver, indicating that the liver is a major site of the HDL assembly. Otherwise, tissue cholesterol homeostasis can largely be maintained in mice even when the assembly of new HDL is inhibited by probucol in the absence of LCAT. Nonspecific diffusion of cholesterol perhaps adequately maintains the homeostasis in the experimental condition.

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Documento generato il 10/04/20 alle ore 02:36:42