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Titolo:
Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice - Pleiotropic effects on CD36 expression and HDL
Autore:
Chen, Z; Ishibashi, S; Perrey, S; Osuga, J; Gotoda, T; Kitamine, T; Tamura, Y; Okazaki, H; Yahagi, N; Iizuka, Y; Shionoiri, F; Ohashi, K; Harada, K; Shimano, H; Nagai, R; Yamada, N;
Indirizzi:
Univ Tokyo, Fac Med, Dept Metab Dis, Bunkyo Ku, Tokyo 1138655, Japan Univ Tokyo Tokyo Japan 1138655 etab Dis, Bunkyo Ku, Tokyo 1138655, Japan Univ Tokyo, Fac Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, Japan Univ Tokyo Tokyo Japan 1138655 vasc Med, Bunkyo Ku, Tokyo 1138655, Japan
Titolo Testata:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
fascicolo: 3, volume: 21, anno: 2001,
pagine: 372 - 377
SICI:
1079-5642(200103)21:3<372:TIAIAE>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED RECEPTOR-GAMMA; LOW-DENSITY LIPOPROTEINS; ZUCKER FATTY RATS; PPAR-GAMMA; INSULIN-RESISTANCE; OXIDIZED LDL; CARDIOVASCULAR-DISEASE; VASCULAR INFLAMMATION; GENE-EXPRESSION; THIAZOLIDINEDIONES;
Keywords:
atherosclerosis; thiazolidinediones; lipoproteins; CD36; peroxisome proliferator-activated receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Ishibashi, S Univ Tokyo, Fac Med, Dept Metab Dis, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan Univ Tokyo 7-3-1 Hongo Tokyo Japan 1138655 yo 1138655, Japan
Citazione:
Z. Chen et al., "Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice - Pleiotropic effects on CD36 expression and HDL", ART THROM V, 21(3), 2001, pp. 372-377

Abstract

Atherosclerotic coronary heart disease is a common complication of the insulin resistance syndrome that can occur with or without diabetes mellitus, Thiazolidinediones (TZDs), which are insulin-sensitizing antidiabetic agents, can modulate the development of atherosclerosis not only by changing thesystemic metabolic conditions associated with insulin resistance but also by exerting direct effects on vascular wall cells that express peroxisome proliferator-activated receptor-gamma (PPAR-gamma), a nuclear receptor for TZDs. Here we show that troglitazone, a TZD, significantly inhibited fatty streak lesion formation in apolipoprotein E-knockout mice fed a high-fat diet (en face aortic surface lesion areas were 6.9+/-2.5% vs 12.7+/-4.7%, P<0.05; cross-sectional lesion areas were 191 974+/-102 911 <mu>m(2) vs 351 738/-175 597 mum(2), P<0.05; n=10). Troglitazone attenuated hyperinsulinemic hyperglycemia and increased high density Lipoprotein cholesterol levels. Inthe aorta, troglitazone markedly increased the mRNA levels of CD36, a scavenger receptor for oxidized low density lipoprotein, presumably by upregulating its expression, at least in part, in the macrophage foam cells. These results indicate that troglitazone potently inhibits fatty streak lesion formation by modulating both metabolic extracellular environments and arterial wall cell functions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 19:35:34