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Titolo:
Parvalbumin expression is downregulated in rat fast-twitch skeletal muscles during aging
Autore:
Cai, DQ; Li, M; Lee, KKH; Lee, KM; Qin, L; Chan, KM;
Indirizzi:
Chinese Univ Hong Kong, Dept Orthopaed & Traumatol, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China Chinese Univ Hong Kong, Dept Anat, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China Chinese Univ Hong Kong, Lee Hysan Clin Res Labs, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China
Titolo Testata:
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
fascicolo: 2, volume: 387, anno: 2001,
pagine: 202 - 208
SICI:
0003-9861(20010315)387:2<202:PEIDIR>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIFFERENT FIBER TYPES; POLYACRYLAMIDE GELS; RELAXATION SPEED; VASTUS LATERALIS; SATELLITE CELLS; STRENGTH; AGE; BINDING; MEN; PROTEINS;
Keywords:
two-dimensional electrophoresis; parvalbumin; aging; exercise; water-soluble muscle protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Chan, KM Chinese Univ Hong Kong, Dept Orthopaed & Traumatol, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China R China
Citazione:
D.Q. Cai et al., "Parvalbumin expression is downregulated in rat fast-twitch skeletal muscles during aging", ARCH BIOCH, 387(2), 2001, pp. 202-208

Abstract

In this study, the protein expression profile of extensor digitorum longous (EDL) and Soleus (SOL) muscles, representing fast- and slow-twitch skeletal muscles, respectively, was established using high resolution two-dimensional electrophoresis (2-DE). One protein spot was found uniquely expressed in EDL muscle. N-terminal sequence analysis identified the protein as parvalbumin. Parvalbumin is a high affinity calcium binding protein that regulates muscle contraction and relaxation. Our experiments revealed that parvalbumin expression in EDL muscle was down-regulated during aging. In addition,high-intensity exercise could reverse this age-related change. Soleus muscles do not normally express parvalbumin, but high-intensity exercise could ectopically induce its expression in both young and old SOL muscles. We have also confirmed our 2-DE findings by immunohistochemistry on muscle sections. Our results suggest that high-intensity training could be used to improve muscle functions during aging because parvalbumin play an important rolein regulating skeletal muscle contraction and relaxation. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 18:03:11