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Titolo:
Frizzled 2 is transiently expressed in neural crest-containing areas during development of the heart and great arteries in the mouse
Autore:
van Gijn, ME; Blankesteijn, WM; Smits, JFM; Hierck, B; Gittenberger-de Groot, AC;
Indirizzi:
Leiden Univ, Med Ctr, Dept Anat & Embryol, NL-2300 RC Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RC NL-2300 RC Leiden, Netherlands Univ Maastricht, Dept Pharmacol, Maastricht, Netherlands Univ Maastricht Maastricht Netherlands armacol, Maastricht, Netherlands
Titolo Testata:
ANATOMY AND EMBRYOLOGY
fascicolo: 3, volume: 203, anno: 2001,
pagine: 185 - 192
SICI:
0340-2061(200103)203:3<185:F2ITEI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLARITY GENE; HUMAN HOMOLOG; SMOOTH-MUSCLE; CELLS; FIBROBLASTS; MORPHOLOGY; EPICARDIUM; SEQUENCES; APOPTOSIS; SEPTATION;
Keywords:
neural crest; frizzled; cardiac morphogenesis; apoptosis; whole body in situ hybridisation; Wnt;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Gittenberger-de Groot, AC Leiden Univ, Med Ctr, Dept Anat & Embryol, POB 9602, NL-2300 RC Leiden, Netherlands Leiden Univ POB 9602 Leiden Netherlands NL-2300 RC
Citazione:
M.E. van Gijn et al., "Frizzled 2 is transiently expressed in neural crest-containing areas during development of the heart and great arteries in the mouse", ANAT EMBRYO, 203(3), 2001, pp. 185-192

Abstract

Frizzled 2 acts as a 7-transmembrane receptor in the Wnt-Dishevelled signal transduction cascade. Among others, this cascade has been associated withneural crest cell proliferation and early migration during development in mammals. The genes for some components of this cascade are located in chromosomal regions that are deleted in human syndromes associated with neural crest cell defects, like DiGeorge and Velo-Cardio-Facial Syndrome. These syndromes are often accompanied by abnormalities in cardiac morphology. Furthermore, we have reported in previous studies the upregulation of the tissue polarity gene frizzled 2 in myofibroblasts during their migration into the necrotic area after myocardial infarction in the adult heart. It is known that genes that are upregulated during cardiac remodeling due to pathology often play a role during development. To investigate whether frizzled 2 can be associated with the process of cardiac morphogenesis we studied its expression in the thoracic arterial system and heart of mouse embryo's of 10, 12, 14, 16 and 18 days after conception by means of in situ hybridization. At day 10 after conception signal could be found in the pharyngeal arches and arch arteries. The outflow tract, the ascending aorta and the pulmonary trunk were positive for frizzled 2 from day 12 on. This expression decreasedwith time and at day 18 only some signal could be detected in the aorta and pulmonary trunk. In contrast, in coronary and pulmonary arteries no expression was observed at any time point. Minor myocardial expression was observed in the ventricular septum at days 12 and 14. Atrial expression, although considerably lower than ventricular expression, could be detected somewhat later at days 14 and 16. Our results indicate that there is transient expression of frizzled 2 in areas that are invested by neural crest cells. This expression is downregulated upon neural crest cell differentiation. The frizzled 2 expression supports a role for the Wnt-frizzled pathway in neuralcrest-related disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:39:54