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Titolo:
Liver diseases by alcohol and hepatitis C: Early detection and new insights in pathogenesis lead to improved treatment
Autore:
Lieber, CS;
Indirizzi:
Bronx VA Med Ctr, Sect Liver Dis & Nutr, Alcohol Res & Treatment Ctr, Bronx, NY 10468 USA Bronx VA Med Ctr Bronx NY USA 10468 & Treatment Ctr, Bronx, NY 10468 USA Mt Sinai Sch Med, New York, NY USA Mt Sinai Sch Med New York NY USAMt Sinai Sch Med, New York, NY USA
Titolo Testata:
AMERICAN JOURNAL ON ADDICTIONS
, volume: 10, anno: 2001, supplemento:, S
pagine: 29 - 50
SICI:
1055-0496(2001)10:<29:LDBAAH>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC ETHANOL-CONSUMPTION; VITAMIN-A DEPLETION; CAROTENE CANCER PREVENTION; CHRONIC HYPERVITAMINOSIS-A; ITO CELL-PROLIFERATION; PERFUSED-RAT-LIVER; CYTOCHROME-P450 2E1; BETA-CAROTENE; OXIDIZING SYSTEM; LIPID-PEROXIDATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
152
Recensione:
Indirizzi per estratti:
Indirizzo: Lieber, CS Bronx VA Med Ctr, Sect Liver Dis & Nutr, Alcohol Res & Treatment Ctr, 151-2,130 W Kingsbridge Rd, Bronx, NY 10468 USA Bronx VA Med Ctr 151-2,130 W Kingsbridge Rd Bronx NY USA 10468
Citazione:
C.S. Lieber, "Liver diseases by alcohol and hepatitis C: Early detection and new insights in pathogenesis lead to improved treatment", AM J ADDICT, 10, 2001, pp. 29-50

Abstract

Much progress has been made in the understanding of the pathogenesis of alcoholic liver disease, resulting in improvement of treatment. Therapy must include correction of nutritional deficiencies, while taking into account changes of nutritional requirements. Methionine is normally activated to S-adenosylmethionine (SAMe). However, in liver disease, the corresponding enzyme is depressed. The resulting deficiencies can be attenuated by the administration of SAMe but not by methionine. Similarly, phosphatidylethanolaminemethyltransferase activity is depressed, but the lacking phosphatidylcholine (PC) can be administrated as polyenylphosphatidylcholine (PPC). Chronic ethanol consumption increases CYP2E1, resulting in increased generation of toxic acetaldehyde and free radicals, tolerance to ethanol and other drugs,and multiple ethanol-drug interactions. Experimentally, PPC apposes CYP2E1induction and fibrosis. Alcoholism and hepatitis C infection commonly, co-exist, with acceleration of fibrosis, cirrhosis, and hepatocellular carcinoma. PPC is being tested clinically as a corresponding antifibrotic agent. Available antiviral agents are contraindicated in the alcoholic. Anti-inflammatory agents, such as steroids, may be selectively useful: Finally, anticraving agents, such as naltrexone or acamprosate, should be part of therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:14:50