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Titolo:
Antibody responses to Plasmodium falciparum: Evolution according to the severity of a prior clinical episode and association with subsequent reinfection
Autore:
Luty, AJF; Ulbert, S; Lell, B; Lehman, L; Schmidt-Ott, R; Luckner, D; Greve, B; Matousek, P; Schmid, D; Herbich, K; Dubois, B; Deloron, P; Kremsner, PG;
Indirizzi:
Univ Tubingen, Inst Trop Med, Dept Parasitol, D-72074 Tubingen, Germany Univ Tubingen Tubingen Germany D-72074 asitol, D-72074 Tubingen, Germany Univ Vienna, Dept Infect Dis, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 ept Infect Dis, A-1090 Vienna, Austria Albert Schweitzer Hosp, Res Unit, Lambarene, Gabon Albert Schweitzer HospLambarene Gabon Hosp, Res Unit, Lambarene, Gabon Hop Bichat, IMEA, INSERM,U13, Malaria Sect, F-75877 Paris, France Hop Bichat Paris France F-75877 U13, Malaria Sect, F-75877 Paris, France CIRMF, Franceville, Gabon CIRMF Franceville GabonCIRMF, Franceville, Gabon
Titolo Testata:
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
fascicolo: 5, volume: 62, anno: 2000,
pagine: 566 - 572
SICI:
0002-9637(200005)62:5<566:ARTPFE>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE MALARIA; CIRCUMSPOROZOITE PROTEIN; SPOROZOITE ANTIBODIES; HOLOENDEMIC AREA; IMMUNE-RESPONSES; ENDEMIC AREA; CHILDREN; IMMUNOGLOBULIN; ANTIGENS; EXPOSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Luty, AJF Univ Tubingen, Inst Trop Med, Dept Parasitol, Wilhelmstr 27, D-72074 Tubingen, Germany Univ Tubingen Wilhelmstr 27 Tubingen Germany D-72074 n, Germany
Citazione:
A.J.F. Luty et al., "Antibody responses to Plasmodium falciparum: Evolution according to the severity of a prior clinical episode and association with subsequent reinfection", AM J TROP M, 62(5), 2000, pp. 566-572

Abstract

We measured sporozoite- and total parasite antigen-specific IgG and IgM antibodies before and after treatment in matched groups of Gabonese children who presented with either mild or severe Plasmodium falciparum malaria. We investigated the influence of Various parameters on these antibody responses, including clinical presentation, age, and post-treatment reinfection profiles. IgG but not IgM responses were strongly influenced by both clinical and parasitological status. IgG responses to the repeat region of the circumsporozoite protein, which were low at admission, particularly so in those with severe anemia, increased after treatment but showed no association with either age or reinfection profiles. Total parasite antigen-specific IgG responses were strongly influenced by parasitological status, and also differed significantly when segregated according to clinical status at admission, age, and reinfection histories. Most notably, anti-parasite IgG responsesmeasured when children were parasite-free were higher and a good indicatorof recent reinfections in those who presented with mild rather than with severe malaria. The profile of responses in the latter group suggests some immune system dysfunction, which may reflect the induction of tolerance to parasite antigens.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 14:34:49