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Titolo:
Delivery systems for penetration enhancement of peptide and protein drugs:design considerations
Autore:
Kompella, UB; Lee, VHL;
Indirizzi:
Univ So Calif, John Stauffer Pharmaceut Sci Ctr, Dept Pharmaceut Sci, Sch Pharm, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 h Pharm, Los Angeles, CA 90089 USA
Titolo Testata:
ADVANCED DRUG DELIVERY REVIEWS
fascicolo: 1-3, volume: 46, anno: 2001,
pagine: 211 - 245
SICI:
0169-409X(20010301)46:1-3<211:DSFPEO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHASEOLUS-VULGARIS LECTINS; SUCKLING RAT ILEUM; INTESTINAL-ABSORPTION COMPONENTS; COAGULASE-NEGATIVE STAPHYLOCOCCI; APPLIED POTENTIAL TOMOGRAPHY; PHARMACEUTICAL DOSAGE FORMS; TRANS-EPITHELIAL TRANSPORT; NON-DISINTEGRATING TABLETS; BRUSH-BORDER MEMBRANE; GROUP-B STREPTOCOCCI;
Keywords:
alveolar deposition; bacterial attachment; gastrointestinal transit; inhaler; lung surfactant; mucoadhesion; mucociliary clearance;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
276
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, VHL Univ So Calif, John Stauffer Pharmaceut Sci Ctr, Dept Pharmaceut Sci, Sch Pharm, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA90089 Los Angeles, CA 90089 USA
Citazione:
U.B. Kompella e V.H.L. Lee, "Delivery systems for penetration enhancement of peptide and protein drugs:design considerations", ADV DRUG DE, 46(1-3), 2001, pp. 211-245

Abstract

This paper discusses the challenges to be met in designing delivery systems that maximize the absorption of peptide and protein drugs from the gastrointestinal and respiratory tracts. The ideal delivery system for either route of administration is one that will release its contents only at a favorable region of absorption, where the delivery system attaches by virtue of specific interaction with surface determinants unique to that region and where the delivery system travels at a rate independent of the transitory constraints inherent of the route of administration. Such a delivery system, which is as yet unavailable, will benefit not only peptide and protein drugs,but other poorly absorbed drugs. (C) 2001 Elsevier Science B.V. All rightsreserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 00:42:12