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Titolo:
TONSILLAR DIFFUSION KINETICS OF AMOXICILLIN AFTER ORAL-ADMINISTRATIONOF 1 G TO ADULTS
Autore:
CHOMARAT M; PANTEIX G; GUILLAUMOND B; DUBREUIL C;
Indirizzi:
CTR HOSP LYON SUD,MICROBIOL LAB F-69310 PIERRE BENITE FRANCE INST PASTEUR LYON FRANCE CTR HOSP LYON SUD,BIOCHIM LAB F-69310 PIERRE BENITE FRANCE HOSP LYON SUD,LAB BACTERIOL CTR PIERRE BENITE FRANCE HOSP LYON SUD,ORL CTR PIERRE BENITE FRANCE
Titolo Testata:
European journal of drug metabolism and pharmacokinetics
fascicolo: 2, volume: 22, anno: 1997,
pagine: 141 - 144
SICI:
0378-7966(1997)22:2<141:TDKOAA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMOXICILLIN;
Keywords:
TONSILLAR DIFFUSION; AMOXICILLIN; HPLC; MICROBIOLOGICAL METHOD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
5
Recensione:
Indirizzi per estratti:
Citazione:
M. Chomarat et al., "TONSILLAR DIFFUSION KINETICS OF AMOXICILLIN AFTER ORAL-ADMINISTRATIONOF 1 G TO ADULTS", European journal of drug metabolism and pharmacokinetics, 22(2), 1997, pp. 141-144

Abstract

Although amoxycillin is widely used to treat pharyngo-tonsillitis, the kinetics of tonsillar diffusion have rarely been studied. The aim ofthis work was to study the kinetics of amoxycillin diffusion in the tonsils of adults, by measuring tonsillar concentrations 1.5, 3, 6 and 12 h after oral administration of 1 g of amoxycillin (Clamoxyl(R) dispersible tablet, 1 g) relative to concomitant serum levels by using an HPLC method and a microbiological technique. At enrollment, the 20 patients were randomly divided into four groups of five, corresponding tothe time intervals (1.5, 3, 6 or 12 h) between the third amoxycillin intake,and the start of surgery. The results given by the two assay methods correlated well (r = 0.92-0.99). Amoxycillin showed excellent penetration into the tonsils, with both tonsillar and serum concentrations exceeding the MIC for most pathogens encountered in this setting (including Streptococcus pyogenes), even 12 h after repeated dosing with1 g of amoxycillin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:14:14