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Titolo:
P39 immunoreactivity in glial cytoplasmic inclusions in brains with multiple system atrophy
Autore:
Honjyo, Y; Kawamoto, Y; Nakamura, S; Nakano, S; Akiguchi, I;
Indirizzi:
Kyoto Univ, Fac Med, Dept Neurol, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 ac Med, Dept Neurol, Kyoto 6068507, Japan
Titolo Testata:
ACTA NEUROPATHOLOGICA
fascicolo: 3, volume: 101, anno: 2001,
pagine: 190 - 194
SICI:
0001-6322(200103)101:3<190:PIIGCI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIN-DEPENDENT KINASE-5; DIRECTED PROTEIN-KINASE; ALPHA-SYNUCLEIN; CDK5 ACTIVATOR; CELLS; EXPRESSION;
Keywords:
cyclin-dependent kinase 5; oligodendrocyte; p39; multiple system atrophy; glial cytoplasmic inclusions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Nakamura, S Kyoto Univ, Fac Med, Dept Neurol, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 Neurol, Kyoto 6068507, Japan
Citazione:
Y. Honjyo et al., "P39 immunoreactivity in glial cytoplasmic inclusions in brains with multiple system atrophy", ACT NEUROP, 101(3), 2001, pp. 190-194

Abstract

Glial cytoplasmic inclusions (GCIs) characteristically occur in the oligodendrocytes of patients with multiple system atrophy (MSA). Cyclin-dependentkinase 5 (Cdk5) regulates cytoskeletal dynamism through phosphorylation ofcytoskeletal proteins such as neurofilament proteins, tau and microtubule-associated protein 2. We examined the immunohistochemical localization of p39, a Cdk5 activator, in human brain specimens obtained post mortem from controls and patients with MSA. Among control specimens, p39 immunoreactivitywas found in some neuronal somata and axons. Similar immunoreactivity was detected in MSA neuronal cell bodies and axons, but a number of inclusions were heavily labeled. These results suggest that p39 and Cdk5 are up-regulated in oligodendrocytes and may be involved in the formation of GCIs through phosphorylation of cytoskeletal proteins in oligodendrocytes in MSA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:51:25