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Titolo:
Pulmonary carcinogenesis induced by ferric nitrilotriacetate in mice and protection from it by Brazilian propolis and artepillin C
Autore:
Kimoto, T; Koya-Miyata, S; Hino, K; Micallef, MJ; Hanaya, T; Arai, S; Ikeda, M; Kurimoto, M;
Indirizzi:
Hayashibara Biochem Labs Inc, Fujisaki Inst, Okayama 7028006, Japan Hayashibara Biochem Labs Inc Okayama Japan 7028006 kayama 7028006, Japan
Titolo Testata:
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY
fascicolo: 3, volume: 438, anno: 2001,
pagine: 259 - 270
SICI:
0945-6317(200103)438:3<259:PCIBFN>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLARA CELL ADENOMA; LIPID-PEROXIDATION; 4-HYDROXY-2-NONENAL-MODIFIED PROTEINS; ULTRASTRUCTURAL FEATURES; MONOCLONAL-ANTIBODY; DNA DAMAGE; MOUSE LUNG; DDY-MICE; CARCINOMA; NEPHROTOXICITY;
Keywords:
ferric nitrilotriacetate; lipid peroxidation; pulmonary tumors; propolis; artepillin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Kimoto, T Hayashibara Biochem Labs Inc, Fujisaki Inst, Fujisaki 675-1, Okayama 7028006, Japan Hayashibara Biochem Labs Inc Fujisaki 675-1 Okayama Japan 7028006
Citazione:
T. Kimoto et al., "Pulmonary carcinogenesis induced by ferric nitrilotriacetate in mice and protection from it by Brazilian propolis and artepillin C", VIRCHOWS AR, 438(3), 2001, pp. 259-270

Abstract

In experiments using the renal carcinogen ferric nitrilotriacetate (Fe-NTA) in male ddY mice, primary pulmonary cancers were also induced in bronchiolar and alveolar tissues. 4-Hydroxy-2-nonenal (4-HNE) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), products of oxidative processes, increased in bronchiolar and alveolar cells after administration of Fe-NTA. These substances disappeared after oral administration of propolis or artepillin C, as shown histochemically, and correlated with an anticancer prophylactic effect of propolis and artepillin C. From our investigation, lipid peroxidation seems toplay an important role in pulmonary carcinogenesis. Malignant progression from adenoma of bronchiolar or alveolar origin to malignant tumors has beenproposed to involve a stepwise transformation. In our study, adenomas developed into adenocarcinomas and large cell carcinomas after treatment with Fe-NTA. In contrast, after oral administration of propolis or artepillin C, adenomas did not progress to carcinomas. Instead of developing into large cell cancers, as induced by Fe-NTA in control mice, adenomas showed remarkable proliferation of macrophages and local anti-oxidant activity after treatment with either propolis or artepillin C. Propolis and artepillin C therefore appear to inhibit lipid peroxidation and the development of pulmonary cancers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 01:56:02