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Titolo:
Limitations of using first-trimester nuchal translucency measurement in routine screening for major congenital heart defects
Autore:
Mavrides, E; Cobian-Sanchez, F; Tekay, A; Moscoso, G; Campbell, S; Thilaganathan, B; Carvalho, JS;
Indirizzi:
Univ London St Georges Hosp, Sch Med, Fetal Med Unit, Acad Dept Obstet & Gynaecol, London SW17 0QT, England Univ London St Georges Hosp London England SW17 0QT on SW17 0QT, England Royal Brompton Hosp, London SW3 6LY, England Royal Brompton Hosp London England SW3 6LY Hosp, London SW3 6LY, England
Titolo Testata:
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
fascicolo: 2, volume: 17, anno: 2001,
pagine: 106 - 110
SICI:
0960-7692(200102)17:2<106:LOUFNT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMOSOMALLY NORMAL FETUSES; LOW-RISK POPULATION; CARDIAC DEFECTS; FETAL HEART; EARLY DIAGNOSIS; DISEASE; GESTATION; ECHOCARDIOGRAPHY; ABNORMALITIES; ULTRASOUND;
Keywords:
cardiac defects; congenital heart disease; prenatal diagnosis; nuchal translucency; screening;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Carvalho, JS Univ London St Georges Hosp, Sch Med, Fetal Med Unit, Acad Dept Obstet & Gynaecol, Lanesborough Wing, London SW17 0QT, England Univ London St Georges Hosp Lanesborough Wing London England SW17 0QT
Citazione:
E. Mavrides et al., "Limitations of using first-trimester nuchal translucency measurement in routine screening for major congenital heart defects", ULTRASOUN O, 17(2), 2001, pp. 106-110

Abstract

Objective To evaluate the effectiveness of nuchal translucency (NT) measurement in screening for major congenital heart disease (CHD) in chromosomally normal fetuses. Design A population based cohort study of all women having fetal NT measurement at 10-14 weeks of gestation in an unselected population over a 3-yearperiod. The outcome measure was the identification of major CHD in chromosomally normal pregnancies either antenatally or postnatally. Results Major defects of the heart and gr eat arteries were identified in 26 out of 7339 pregnancies (prevalence 3.5 per 1000 pregnancies). Out of 26cases, only four (sensitivity 15.4%, 95% CI 4-35) were in the group of 258pregnancies (3.5%) with increased NT of greater than or equal to 2.5 mm. The prevalence of major CHD increased from 3.1 per 1000 for NT < 2.5 mm to 50 per 1000 for NT <greater than or equal to> 3.5 mm (likelihood ratio of 14.1, 95% CI 4.2-47.9). The positive and negative predictive values for NT greater than or equal to 2.5 mm were 1.6% and 99.7%, respectively. Conclusions The prevalence of major CHD in this study was 3.5 per 1000, suggesting that ascertainment of CHD in our study population was thorough. Fetuses with NT measurements greater than or equal to 3.5 mm have a significantly increased risk of major CHD, and this identifies a subgroup of high-risk patients in whom early fetal echocardiography would be advocated The late sensitivity of NT for major CHD in the general population, however, indicates that NT cannot be relied on as the sole or major screening tool for this condition as previously reported.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 00:34:17