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Titolo:
Neurotoxicological outcomes of perinatal heptachlor exposure in the rat
Autore:
Moser, VC; Shafer, TJ; Ward, TR; Meacham, CA; Harris, MW; Chapin, RE;
Indirizzi:
US EPA, NTD MD74B, Div Neurotoxicol,Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA27711 es Lab, Res Triangle Pk, NC 27711 USA NIEHS, Reprod Toxicol Grp, Natl Toxicol Program, Res Triangle Pk, NC 27709USA NIEHS Res Triangle Pk NC USA 27709 Program, Res Triangle Pk, NC 27709USA
Titolo Testata:
TOXICOLOGICAL SCIENCES
fascicolo: 2, volume: 60, anno: 2001,
pagine: 315 - 326
SICI:
1096-6080(200104)60:2<315:NOOPHE>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROBEHAVIORAL SCREENING BATTERY; BRAIN-STEM; PRENATAL EXPOSURE; CHLORIDE TRANSPORT; PESTICIDE DIELDRIN; GABA(A) RECEPTORS; MONOAMINE NEURONS; IN-VITRO; LINDANE; INSECTICIDES;
Keywords:
heptachlor; developmental neurotoxicity; Morris water maze; pesticide exposure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Moser, VC US EPA, NTD MD74B, Div Neurotoxicol,Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA US EPA Res TrianglePk NC USA 27711 s Triangle Pk, NC 27711 USA
Citazione:
V.C. Moser et al., "Neurotoxicological outcomes of perinatal heptachlor exposure in the rat", TOXICOL SCI, 60(2), 2001, pp. 315-326

Abstract

The developing nervous system has been identified as a potential target ofpesticide exposure. Heptachlor is a cyclodiene pesticide that was widely used for many years, and for which inadvertent exposure to children and fetuses took place in the early 1980s; yet little is known regarding the developmental neurotoxicity of it and other cyclodienes. The aim of this study was to determine whether perinatal heptachlor exposure results in persistent alterations in nervous system function, Pregnant Sprague-Dawley dams were dosed from gestational day (GD) 12 to postnatal day (PND) 7, whereupon the rat pups were dosed directly until PND 21 (group A) or PND 42 (group B), Dose levels were 0, 0.03, 0,3, or 3 mg/kg/day, po, There were no dose-related effects on maternal weight, litter size, or pup growth. GABA, receptor binding (using [S-35] tert-butylbicyclophosphotothionate; TBPS) and GABA-stimulated Cl- flux were evaluated in control and high-dose brain tissues taken on PND 7, 21, and 43, The B-max values for [S-35]-TBPS binding in brainstem,but not cortex, were decreased in female rats across all ages tested. There were no such changes in male rats, nor were K-D values altered in either tissue or gender. GABA-stimulated Cl- flux was decreased in female cortex synaptoneurosomes only on PND 21, The ontogeny of the righting response (PND2-5) was delayed in the high-dose females. All subsequent testing took place a week to months after dosing ceased. The functional observational battery (FOB) showed treatment-related, but not necessarily dose-related, changes in different aspects of the rat's reactivity and activity levels. Group-Arats also showed altered within-session habituation of motor activity. There were no heptachlor-related differences in motor activity following challenge with a range of chlordiazepoxide doses. Cognitive assessments were conducted in both groups of rats. There were no statistically significant differences among treatment groups in a one-trial passive avoidance test, although there was a trend toward less learning. In group B, rats (both sexes), heptachlor altered spatial learning in the Morris water maze during two weeks of daily training (2 trials/day). On probe trials, heptachlor-treated rats did not show significant preference for the correct quadrant tall dose groups in males, high dose in females). These rats did not show alterations on subsequent working-memory training (where the platform position was relearned each day). Thus, perinatal exposure to heptachlor produced neurochemical and persistent neurobehavioral changes, including alterations in spatial learning and memory,

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Documento generato il 29/03/20 alle ore 23:15:15