Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The effect of pregnancy on renal clearance of boron in rats given boric acid orally
Autore:
Vaziri, ND; Oveisi, F; Culver, BD; Pahl, MV; Andersen, ME; Strong, PL; Murray, FJ;
Indirizzi:
Univ Calif Irvine, Dept Med, Div Nephrol & Hypertens, Irvine, CA 92697 USAUniv Calif Irvine Irvine CA USA 92697 l & Hypertens, Irvine, CA 92697 USA Univ Calif Irvine, Dept Med, Div Epidemiol, Irvine, CA 92697 USA Univ Calif Irvine Irvine CA USA 92697 Div Epidemiol, Irvine, CA 92697 USA Colorado State Univ, Ft Collins, CO 80532 USA Colorado State Univ Ft Collins CO USA 80532 niv, Ft Collins, CO 80532 USA US Borax Inc, Valencia, CA 91355 USA US Borax Inc Valencia CA USA 91355US Borax Inc, Valencia, CA 91355 USA Murray & Associates, San Jose, CA 95138 USA Murray & Associates San Jose CA USA 95138 ociates, San Jose, CA 95138 USA
Titolo Testata:
TOXICOLOGICAL SCIENCES
fascicolo: 2, volume: 60, anno: 2001,
pagine: 257 - 263
SICI:
1096-6080(200104)60:2<257:TEOPOR>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIETARY BORON; UNCERTAINTY FACTORS; RISK ASSESSMENT; TOXICITY; PHARMACOKINETICS; METABOLISM; NUTRITION; RECOVERY; INDEXES; RODENTS;
Keywords:
boric acid; boron; pregnancy; rats; clearance; half-life;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Vaziri, ND UCI, Med Ctr, 101 The City Dr, Orange, CA 92868 USA UCI 101 TheCity Dr Orange CA USA 92868 r, Orange, CA 92868 USA
Citazione:
N.D. Vaziri et al., "The effect of pregnancy on renal clearance of boron in rats given boric acid orally", TOXICOL SCI, 60(2), 2001, pp. 257-263

Abstract

Boric acid (H3BO3) has been shown to cause developmental abnormalities in the offspring of pregnant rats. Comparative data on the renal clearance of baron (B) in rats and humans, both pregnant and nonpregnant, exposed to boric acid (BA) would reduce uncertainty in interspecies extrapolation from rats to humans. The purpose of this study was to evaluate the effect of pregnancy on the plasma half-life and renal clearance of baron in Sprague-Dawleyrats given a single oral dose of boric acid. Far the half-life study, nonpregnant and pregnant (gestation day 16) rats were given a single dose of 30mg/kg of boric acid by gavage, and plasma samples were collected at 2-3 h intervals. The plasma half-life of boron was determined to be 2.9 +/- 0.2 and 3.2 +/- 0.3 h in nonpregnant and pregnant rats, respectively. In the clearance study, nonpregnant and pregnant (GD 16) rats were given a single gavage dose of 0.3, 3, or 30 mg/kg of boric acid. Boron clearance was slightlyhigher in pregnant rats(3.3 +/- 0.6, 3.2 +/- 0.5, and 3.4 +/- 0.5 ml/min/kg, respectively) compared to nonpregnant rats (3.1 +/- 0.8, 3.0 +/- 0.6, and 3.2 +/- 0.5 ml/min/kg, respectively), but the difference was not statistically significant and not dose-related. Baron clearance was less than creatinine clearance, suggesting tubular reabsorption in both groups. In conclusion, pregnancy did not appear to significantly alter the renal clearance orthe plasma half-life of boron in Sprague-Dawley rats under the conditions of this study.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:32:51