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Titolo:
Serum concentrations of fluoxetine in the clinical treatment setting
Autore:
Lundmark, J; Reis, M; Bengtsson, F;
Indirizzi:
Linkoping Univ Hosp, Dept Neurosci & Locomot, Div Psychiat, S-58185 Linkoping, Sweden Linkoping Univ Hosp Linkoping Sweden S-58185 , S-58185 Linkoping, Sweden Univ Lund Hosp, Dept Clin Pharmacol, Inst Lab Med, Lund, Sweden Univ Lund Hosp Lund Sweden t Clin Pharmacol, Inst Lab Med, Lund, Sweden
Titolo Testata:
THERAPEUTIC DRUG MONITORING
fascicolo: 2, volume: 23, anno: 2001,
pagine: 139 - 147
SICI:
0163-4356(200104)23:2<139:SCOFIT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN REUPTAKE INHIBITORS; HUMAN LIVER-MICROSOMES; AZOLE ANTIFUNGAL AGENTS; METABOLISM IN-VITRO; EXTENSIVE METABOLIZERS; PLASMA-CONCENTRATIONS; NORFLUOXETINE; ANTIDEPRESSANTS; ENANTIOMERS; PHARMACOKINETICS;
Keywords:
therapeutic drug monitoring; serum concentration; selective serotonin reuptake inhibitors; fluoxetine; elderly;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Lundmark, J Linkoping Univ Hosp, Dept Psychiat, S-58185 Linkoping, Sweden Linkoping Univ Hosp Linkoping Sweden S-58185 nkoping, Sweden
Citazione:
J. Lundmark et al., "Serum concentrations of fluoxetine in the clinical treatment setting", THER DRUG M, 23(2), 2001, pp. 139-147

Abstract

This article discusses fluoxetine serum concentrations as displayed in a clinical setting. A racemic serum fluoxetine and norfluoxetine high-performance liquid chromatography method, including ultraviolet light detection, was used for routine therapeutic drug monitoring (TDM) purposes. In all, 508 samples were analyzed. For the scientific investigation, predefined inclusion and exclusion criteria were applied and 150 samples representative of trough values in steady-stale conditions with essential clinical information provided on the assay request forms were evaluated, Fluoxetine plus norfluoxetine concentration-to-dose (C/D) ratio showed Gaussian distribution. Interindividual coefficients of variation of fluoxetine and norfluoxetine serumconcentrations after different doses were found to be 40-63%. Intraindividual fluoxetine TDM variability was low. The Spearman rank correlation coefficient for fluoxetine and norfluoxetine C/D ratios in first and second samples was 0.68. Minor increases in norfluoxetine C/D and fluoxetine plus norfluoxetine C/D ratios were found in elderly patients compared with younger adult patients. A higher body-mass index was associated with minor decreasesin fluoxetine and fluoxetine plus norfluoxetine C/D ratios. New fluoxetinepharmacokinetic data are added to the results from earlier phases of drug development. Moreover, the results of this study support the usefulness of a fluoxetine TDM procedure for individual dose optimization, detection of drug interactions, and assessments of patient compliance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:32:32