Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effect of hemodialysis membranes on beta(2)-microglobulin amyloidosis
Autore:
Jaradat, MI; Moe, SM;
Indirizzi:
Indiana Univ, Sch Med, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 ch Med, Indianapolis, IN 46202 USA Richard L Roudebush Vet Adm Med Ctr, Indianapolis, IN 46202 USA Richard L Roudebush Vet Adm Med Ctr Indianapolis IN USA 46202 N 46202 USA
Titolo Testata:
SEMINARS IN DIALYSIS
fascicolo: 2, volume: 14, anno: 2001,
pagine: 107 - 112
SICI:
0894-0959(200103)14:2<107:EOHMOB>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARPAL-TUNNEL SYNDROME; AMBULATORY PERITONEAL-DIALYSIS; RESIDUAL RENAL-FUNCTION; LONG-TERM HEMODIALYSIS; BETA-2-MICROGLOBULIN REMOVAL; SERUM BETA-2-MICROGLOBULIN; POLYSULFONE DIALYZERS; DESTRUCTIVE SPONDYLOARTHROPATHY; I-131 BETA-2-MICROGLOBULIN; MAINTENANCE HEMODIALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
90
Recensione:
Indirizzi per estratti:
Indirizzo: Jaradat, MI Indiana Univ, Sch Med, 1001 W 10th St,OPW 5261, Indianapolis, IN 46202 USA Indiana Univ 1001 W 10th St,OPW 5261 Indianapolis IN USA 46202
Citazione:
M.I. Jaradat e S.M. Moe, "Effect of hemodialysis membranes on beta(2)-microglobulin amyloidosis", SEMIN DIAL, 14(2), 2001, pp. 107-112

Abstract

Early after the identification of beta (2)-microglobulin amyloidosis (A beta M-2) as the cause of carpal tunnel syndrome, it was thought that hemodialysis was a major cause in the development of the disease. It was subsequently shown that hemodialysis was not necessary for the development of dialysis-related amyloidosis; however, it was believed that the different dialysis membranes did modulate the progression of the disease. Current data demonstrate that hemodialysis fails to prevent or reverse the disease, but thereis substantial evidence that high-flux, high-efficiency dialyzers slow itsprogression. Many factors related to hemodialysis have been evaluated in relation to A beta M-2, including the effect of the bioincompatibility of the membrane, the capacity of the different membranes to remove beta M-2, andthe effect of reuse on beta M-2 levels. Moreover, there have been intensive efforts to evaluate, explore, and improve the different mechanisms in beta M-2 removal, with adsorption as a promising prospect. With the available evidence, it seems that the removal of beta M-2 by the membrane plays the most important role in modulating the disease outcome and rate of progression, although a large, long-term, multicentered and randomized study is stilllacking to prove this relationship. However, it is possible that with the continuing advances in optimizing the beta M-2 removal efficiency of the different membranes, the frequency and severity of the disease can be substantially decreased.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:51:39