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Titolo:
Vertical HIV-1 transmission: Importance of neutralizing antibody titer andspecificity
Autore:
Bongertz, V; Costa, CI; Veloso, VG; Grinsztejn, B; Joao, EC; Calvet, G; Pilotto, JH; Guimaraes, ML; Morgado, MG;
Indirizzi:
FIOCRUZ, IOC, Dept Imunol, AIDS & Imunol Mol Lab, BR-21045900 Rio De Janeiro, Brazil FIOCRUZ Rio De Janeiro Brazil BR-21045900 BC45900 Rio De Janeiro, Brazil FIOCRUZ, Evandro Chagas Hosp Res Ctr, BR-21045900 Rio De Janeiro, Brazil FIOCRUZ Rio De Janeiro Brazil BR-21045900 BC45900 Rio De Janeiro, Brazil Serv Estado Hosp, Rio De Janeiro, Brazil Serv Estado Hosp Rio De JaneiroBrazil ado Hosp, Rio De Janeiro, Brazil Nova Iguacu Gen Hosp, Rio De Janeiro, Brazil Nova Iguacu Gen Hosp Rio De Janeiro Brazil Hosp, Rio De Janeiro, Brazil
Titolo Testata:
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
fascicolo: 3, volume: 53, anno: 2001,
pagine: 302 - 309
SICI:
0300-9475(200103)53:3<302:VHTION>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; MATERNAL-INFANT TRANSMISSION; TO-CHILD TRANSMISSION; PERINATAL TRANSMISSION; ANTIRETROVIRAL THERAPY; ZIDOVUDINE TREATMENT; VIRAL PHENOTYPE; TYPE-1 HIV-1; RISK-FACTORS; INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Bongertz, V FIOCRUZ, IOC, Dept Imunol, AIDS & Imunol Mol Lab, Av Brasil 4365, BR-21045900 Rio De Janeiro, Brazil FIOCRUZ Av Brasil 4365 Rio De Janeiro Brazil BR-21045900 BCil
Citazione:
V. Bongertz et al., "Vertical HIV-1 transmission: Importance of neutralizing antibody titer andspecificity", SC J IMMUN, 53(3), 2001, pp. 302-309

Abstract

Neutralization analyses were carried out with plasma from 132 volunteer human immunodeficiency virus (HIV)-1 infected women (76% pregnant, 24% with infants suspected for HIV-1 infection) collected between 1994 and 1998, against autologous and heterologous primary- and the reference HIV-1 MN isolates. A significantly lower percentage of HIV-1 transmissions was observed after 1996, parallel to a more intense antiretroviral treatment of infected pregnant women. HIV-1 isolation was significantly more frequent from peripheral blood mononuclear cells of mothers of infected children than mothers of uninfected children (P = 0.0065). Neutralization of autologous HIV-1 isolates was comparable for HIV-1 transmitters and nontransmitters' plasma, whereas neutralization of the reference isolate HIV-1 MN was more frequent at high titers for pregnant women who did not transmit HIV to their offspring compared to pregnant women who did. Although neutralization of heterologous primary HIV-1 isolates from HIV transmitters and non transmitters by transmitter plasma occurred with similar frequency, neutralization of isolates from transmitters was much more frequent when heterologous plasma from nontransmitters were used. Macrophage-tropic heterologous HIV-1 isolates were neutralized more frequently at higher titers by plasma from nontransmitters than from transmitters. The results obtained indicate that antiretroviral treatment, lack of success of HIV-1 isolation and high titers of antibodies able to neutralize macrophage-tropic viruses appear to be of importance for protection against HIV-1 vertical transmission for the group of patients studied.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 15:16:24