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Titolo:
Transforming growth factor-alpha delays gastric emptying and small intestinal transit in suckling rats
Autore:
Shinohara, H; Williams, CS; McWilliam, DL; Koldovsky, O; Philipps, AF; Dvorak, B;
Indirizzi:
Univ Arizona, Dept Pediat, Tucson, AZ 85724 USA Univ Arizona Tucson AZ USA 85724 izona, Dept Pediat, Tucson, AZ 85724 USA Univ Arizona, Steele Mem Childrens Res Ctr, Tucson, AZ 85724 USA Univ Arizona Tucson AZ USA 85724 Childrens Res Ctr, Tucson, AZ 85724 USA
Titolo Testata:
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
fascicolo: 4, volume: 36, anno: 2001,
pagine: 356 - 360
SICI:
0036-5521(200104)36:4<356:TGFDGE>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTROINTESTINAL-TRACT; FACTOR RECEPTOR; CELL-MIGRATION; MESSENGER-RNA; FACTOR-BETA; POLY R-478; EXPRESSION; STOMACH; MUCOSA; MILK;
Keywords:
gastrointestinal motility; intestinal transit; suckling rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Dvorak, B Univ Arizona, Dept Pediat, 1501 N Campbell Ave, Tucson, AZ 85724USA Univ Arizona 1501 N Campbell Ave Tucson AZ USA 85724 Z 85724 USA
Citazione:
H. Shinohara et al., "Transforming growth factor-alpha delays gastric emptying and small intestinal transit in suckling rats", SC J GASTR, 36(4), 2001, pp. 356-360

Abstract

Transforming growth factor-alpha (TGF-alpha) is a biologically patent polypeptide detected in the gastrointestinal tract in suckling rats. The major goal of the present study was to test the hypothesis that the administration of TGF-alpha affects gastric emptying and small intestinal transit in suckling rats. Suckling (12-day-old) rats fasted 16 h received rat TGF-alpha subcutaneously (s.c.) or orogastrically in varying doses (0, 0.5, 1.0 mug/rat in 0.1% BSA). Control animals received 0.1% BSA only. Poly R-478 dye was used as a motility marker. Rats were decapitated 45 min after marker administration and the amount of dye in the stomach and the small intestine was measured by spectrophotometry. Subcutaneous administration of TGF-alpha significantly delayed stomach evacuation. In controls, the stomach contained 21.4 +/- 1.4% (mean +/- s(x)) of the Poly R-478 marker, whereas in TGF-alpha treated rats the stomach contained 37.2 +/- 2.8% of the total Poly R-478 dye given to animals. The delaying effect of TGF-alpha was time- and dose-dependent. Small intestinal transit was also significantly delayed. The proximal jejunum of TGF-alpha treated rats contained a 1.4-fold higher amount of marker in comparison with control rats. Orogastrically administered rTGF-alpha did not affect gastric emptying or intestinal transit. In conclusion, s.c. administration of rat TGF-alpha significantly delayed the gastrointestinal motility in vivo in suckling rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 05:42:56