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Titolo:
Efficacy and safety of dipyrone versus tramadol in the management of pain after hysterectomy: A randomized, double-blind, multicenter study
Autore:
Torres, LM; Rodriguez, MJ; Montero, A; Herrera, J; Calderon, E; Cabrera, J; Porres, R; de la Torre, MR; Martinez, T; Gomez, JL; Ruiz, J; Garcia-Magaz, I; Camara, J; Ortiz, P;
Indirizzi:
Hosp Univ Puerta Mar, Unidad Dolor, Serv Anestesia, Dept Anesthesiol,Crit Care & Pain Clin, E-11009 Cadiz, Spain Hosp Univ Puerta Mar Cadiz Spain E-11009 Pain Clin, E-11009 Cadiz, Spain Hosp Univ Carlos Haya, Malaga, Spain Hosp Univ Carlos Haya Malaga SpainHosp Univ Carlos Haya, Malaga, Spain Hosp Univ Arnau Vilanova, Lleida, Spain Hosp Univ Arnau Vilanova Lleida Spain niv Arnau Vilanova, Lleida, Spain Hosp Univ Valme, Seville, Spain Hosp Univ Valme Seville SpainHosp Univ Valme, Seville, Spain Boehringer Ingelheim Espana, Dept Stat, Madrid, Spain Boehringer IngelheimEspana Madrid Spain pana, Dept Stat, Madrid, Spain Boehringer Ingelheim Espana, Dept Med, Madrid, Spain Boehringer Ingelheim Espana Madrid Spain spana, Dept Med, Madrid, Spain
Titolo Testata:
REGIONAL ANESTHESIA AND PAIN MEDICINE
fascicolo: 2, volume: 26, anno: 2001,
pagine: 118 - 124
SICI:
1098-7339(200103/04)26:2<118:EASODV>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PATIENT-CONTROLLED ANALGESIA; POSTOPERATIVE PAIN; LYSINE-ACETYLSALICYLATE; CONTINUOUS-INFUSION; METAMIZOL DIPYRONE; ABDOMINAL-SURGERY; INTRAVENOUS ROUTE; MORPHINE; PLACEBO;
Keywords:
dipyrone; tramadol; hysterectomy; patient controlled analgesia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Torres, LM Hosp Univ Puerta Mar, Unidad Dolor, Serv Anestesia, Dept Anesthesiol,Crit Care & Pain Clin, Ana Viya 21, E-11009 Cadiz, Spain Hosp Univ Puerta Mar Ana Viya 21 Cadiz Spain E-11009 iz, Spain
Citazione:
L.M. Torres et al., "Efficacy and safety of dipyrone versus tramadol in the management of pain after hysterectomy: A randomized, double-blind, multicenter study", REG ANES PA, 26(2), 2001, pp. 118-124

Abstract

Background and Objectives: We assessed the efficacy and safety of dipyronein comparison with tramadol in the relief of early postoperative pain following abdominal hysterectomy. Methods: A total of 151 women between 18 and 60 years of age undergoing abdominal hysterectomy during general anesthesia participated in a randomized, double-blind, controlled, multicenter study. Seventy-three patients received dipyrone and 78 received tramadol. Patients received an intravenous loading dose of the study drug immediately after operation followed by intravenous (TV) maintenance infusion and IV on-demand boluses up to a maximum number of predetermined doses/day of 8 g dipyrone and 500 mg tramadol. The duration of the study was 24 hours. Results: The mean (SD) number of boluses in the dipyrone group was 3.8 (2.4) and 3.5 (2.5) in the tramadol group (95% confidence interval, -0.455 to 1.175), and the percentage of patients requiring rescue IV morphine (dipyrone 26.9%, tramadol 26.8%) was not statistically significant. Other analgesic efficacy parameters, such as pain intensity differences, sum of pain intensity differences, pain relief assessed by the patient, or patients who required the maximum number of demand doses, were not different between treatment groups. A significantly higher percentage of adverse gastrointestinal effects was found in patients given tramadol (42.1%) than in patients given dipyrone (20.2%) (P < .05). Also, a significantly higher number of tramadol-treated patients required ondansetron to control nausea and vomiting at 1 hour (19% v 7%), 2 hours (26% v 11%), and 24 hours (46% v 29%) (P < .05) after surgery. Patients and the investigators reported similar tolerability for both study arms. Conclusions: Dipyrone and tramadol showed similar efficacy for early pain relief after abdominal hysterectomy. Nausea and vomiting, possibly caused by the tramadol, occurred more frequently in those patients. In this group, the need of the antiemetic drug ondansetron was also higher.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 14:03:56