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Titolo:
Quantified power Doppler US of tumor blood flow correlates with microscopic quantification of tumor blood vessels
Autore:
Donnelly, EF; Geng, L; Wojcicki, WE; Fleischer, AC; Hallahan, DE;
Indirizzi:
Vanderbilt Univ, Med Ctr, Dept Radiol, Vanderbilt Clin, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 bilt Clin, Nashville, TN 37232 USA Vanderbilt Univ, Med Ctr, Dept Radiat Oncol, Vanderbilt Clin, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 bilt Clin, Nashville, TN 37232 USA Vanderbilt Univ, Med Ctr, Dept Biomed Engn, Vanderbilt Clin, Nashville, TN37232 USA Vanderbilt Univ Nashville TN USA 37232 rbilt Clin, Nashville, TN37232 USA
Titolo Testata:
RADIOLOGY
fascicolo: 1, volume: 219, anno: 2001,
pagine: 166 - 170
SICI:
0033-8419(200104)219:1<166:QPDUOT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
VON-WILLEBRAND-FACTOR; COLOR-DOPPLER; IONIZING-RADIATION; HEPATOCELLULAR-CARCINOMA; ENDOTHELIAL-CELLS; SONOGRAPHY; VASCULARITY; THERAPY; LIVER; MODEL;
Keywords:
animals; blood vessels, abnormalities; blood vessels, US; therapeutic radiology, experimental studies; ultrasound (US), experimental studies; ultrasound (US), power Doppler studies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Hallahan, DE Vanderbilt Univ, Med Ctr, Dept Radiol, Vanderbilt Clin, 1301 22nd Ave S,B-902, Nashville, TN 37232 USA Vanderbilt Univ 1301 22nd Ave S,B-902 Nashville TN USA 37232
Citazione:
E.F. Donnelly et al., "Quantified power Doppler US of tumor blood flow correlates with microscopic quantification of tumor blood vessels", RADIOLOGY, 219(1), 2001, pp. 166-170

Abstract

PURPOSE: To evaluate the ability of a quantified power Doppler ultrasonography (US) system to help quantitate differences in tumor vascularity after radiation therapy and administration of tumor necrosis factor (TNF). MATERIALS AND METHODS: Murine glioblastoma tumors were grown in the thighsof two sets of 25 mice each. Each mouse was assigned to one of four treatment groups: control (no treatment), radiation therapy, TNF therapy, or combination therapy (both radiation and TNF therapies). Mice were then evaluated with quantified power Doppler US, and a vascularity index (color area) was calculated for different tumor regions in each group. The tumors were then excised, and histologic evaluation was performed by using an immunofluorescence-tagged monoclonal antibody against blood vessel endothelium. The number of stained blood vessels per high-power field was correlated with the sonographically determined vascularity index. RESULTS: The color area of the total tumor decreased to 37% of that in thecontrol group in mice treated with radiation therapy alone (P = .02), 26% of that in the control group in mice treated with TNF alone (P = .05), and 8% of that in the control group in those treated with both TNF and radiation (P = .006). These results correlated well with the quantified results from immunofluorescent staining (r = 0.98). CONCLUSION: Quantified power Doppler US is a noninvasive method for the evaluation of tumor vascularity and blood flow.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 16:08:02