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Titolo:
Prepulses reduce the pain of cutaneous electrical shocks
Autore:
Blumenthal, TD; Burnett, TT; Swerdlow, CD;
Indirizzi:
Wake Forest Univ, Dept Psychol, Winston Salem, NC 27109 USA Wake Forest Univ Winston Salem NC USA 27109 , Winston Salem, NC 27109 USA Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA Cedars Sinai Med Ctr Los Angeles CA USA 90048 , Los Angeles, CA 90048 USA
Titolo Testata:
PSYCHOSOMATIC MEDICINE
fascicolo: 2, volume: 63, anno: 2001,
pagine: 275 - 281
SICI:
0033-3174(200103/04)63:2<275:PRTPOC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; ACOUSTIC STARTLE RESPONSE; INHIBITION; TERMINATION; PRESTIMULI; EYEBLINK; STIMULI; DISEASE; NEURONS;
Keywords:
implantable cardioverter/defibrillator; prepulse inhibition; pain; startle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Blumenthal, TD Wake Forest Univ, Dept Psychol, Winston Salem, NC 27109 USAWake Forest Univ Winston Salem NC USA 27109 , NC 27109 USA
Citazione:
T.D. Blumenthal et al., "Prepulses reduce the pain of cutaneous electrical shocks", PSYCHOS MED, 63(2), 2001, pp. 275-281

Abstract

Objective: Both the startle reflex elicited by an intense acoustic or tactile stimulus and the perceived intensity of that stimulus can be diminishedby a weak "prepulse" that precedes the startling stimulus. The present study examined whether prepulses can also diminish the pain produced by an intense electrical stimulus similar to that used to treat life-threatening cardiac arrhythmias in conscious patients with implantable cardioverter/defibrillators or transcutaneous pacemakers. Methods: Perceptual and pain thresholds for electrical shocks to the arm were determined in 20 adults. Participants then rated the painfulness of 25 electrical shocks that were 1.5 timesthe pain threshold (mean shock intensity, approximate to 160 V) and eitherpresented alone or preceded (at 40-60 ms) by weak electrical prepulses equal to or 25% above the perceptual threshold, Results: Prepulses significantly reduced the pain produced by the intense shocks. Individuals with the lowest pain thresholds experienced the greatest pain reduction with prepulses, In these more sensitive individuals, the most effective prepulses reducedperceived pain by 26% across the entire test session and by 54% in the initial block of five shocks, Conclusions: Prepulses may be useful in diminishing the pain associated with the therapeutic electrical shocks used to treat cardiac arrhythmias.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 21:11:37