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Titolo:
Ten year progressive ventricular enlargement in schizophrenia: An MRI morphometrical study
Autore:
Saijo, T; Abe, T; Someya, Y; Sassa, T; Sudo, Y; Suhara, T; Shuno, T; Asai, K; Okubo, Y;
Indirizzi:
Tokyo Med & Dent Univ, Fac Med, Sch Allied Hlth Sci, Sect Clin Physiol,Bunkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ Tokyo Japan 1138519 unkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ, Grad Sch, Sect Psychiat & Behav Sci, Tokyo, Japan Tokyo Med & Dent Univ Tokyo Japan ct Psychiat & Behav Sci, Tokyo, Japan Asai Hosp, Chiba, Japan Asai Hosp Chiba JapanAsai Hosp, Chiba, Japan Japan Sci & Technol Corp, CREST, Chiba, Japan Japan Sci & Technol Corp Chiba Japan Technol Corp, CREST, Chiba, Japan Natl Inst Radiol Sci, Div Adv Technol & Med Imaging, Chiba 260, Japan NatlInst Radiol Sci Chiba Japan 260 nol & Med Imaging, Chiba 260, Japan
Titolo Testata:
PSYCHIATRY AND CLINICAL NEUROSCIENCES
fascicolo: 1, volume: 55, anno: 2001,
pagine: 41 - 47
SICI:
1323-1316(200102)55:1<41:TYPVEI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHILDHOOD-ONSET SCHIZOPHRENIA; BRAIN STRUCTURAL-CHANGE; ADOLESCENCE; MORPHOLOGY; STABILITY; DISORDER; SIZE;
Keywords:
follow up; lateral ventricles; MRI; progression; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Okubo, Y Tokyo Med & Dent Univ, Fac Med, Sch Allied Hlth Sci, Sect Clin Physiol,Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138519, Japan Tokyo Med & Dent Univ1-5-45 Yushima Tokyo Japan 1138519 , Japan
Citazione:
T. Saijo et al., "Ten year progressive ventricular enlargement in schizophrenia: An MRI morphometrical study", PSY CLIN N, 55(1), 2001, pp. 41-47

Abstract

Recent studies of the brain using magnetic resonance imaging (MRI) have suggested progressive structural changes in schizophrenics. However, those studies were conducted over periods of less than 5 years and thus lacked sufficient capacity to determine the course and nature of this process. In thisstudy, MRI scans were obtained in 15 schizophrenics and 12 controls at baseline and after 4- and 10-year follow ups. Volumes of the lateral ventricles were measured. Patients were assessed by the Brief Psychiatric Rating Scale (BPRS) at the same two time points: at baseline and at 10-year follow up. After 10 years, a significant lateral ventricular enlargement was found in patients (mean percentage change: +22.9%) but not in controls (5.1%). Although our results are not in disagreement with the neurodevelopmental hypothesis, they do provide strong evidence that in schizophrenia progressive brain reduction occurs even in its chronic stage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 12:57:58