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Titolo:
Effects of transdermal application of 7-oxo-DHEA on the levels of steroid hormones, gonadotropins and lipids in healthy men
Autore:
Sulcova, J; Hill, M; Masek, Z; Ceska, R; Novacek, A; Hampl, R; Starka, L;
Indirizzi:
Charles Univ, Fac Med 1, Inst Endocrinol, Prague 11694, Czech Republic Charles Univ Prague Czech Republic 11694 l, Prague 11694, Czech Republic Charles Univ, Fac Med 1, Dept Internal Med 3, Prague 11694, Czech RepublicCharles Univ Prague Czech Republic 11694 3, Prague 11694, Czech Republic AREKO Ltd, Prague, Czech Republic AREKO Ltd Prague Czech RepublicAREKO Ltd, Prague, Czech Republic
Titolo Testata:
PHYSIOLOGICAL RESEARCH
fascicolo: 1, volume: 50, anno: 2001,
pagine: 9 - 18
SICI:
0862-8408(2001)50:1<9:EOTAO7>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEHYDROEPIANDROSTERONE DHEA; WOMEN; REPLACEMENT; AGE;
Keywords:
7-xoo-DHEA; transdermal application; sex hormones; lipids; LH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Sulcova, J Charles Univ, Fac Med 1, Inst Endocrinol, Narodni 8, Prague 11694, Czech Republic Charles Univ Narodni 8 Prague Czech Republic 11694 ch Republic
Citazione:
J. Sulcova et al., "Effects of transdermal application of 7-oxo-DHEA on the levels of steroid hormones, gonadotropins and lipids in healthy men", PHYSL RES, 50(1), 2001, pp. 9-18

Abstract

The aim of this study was to investigate the effect of 7-oxo-DHEA (dehydroepiandrosterone) on the serum levels of steroid sexual hormones, gonadotropins, lipids and lipoproteins in men. 7-oxo-DHEA was applied onto the skin as a gel to 10 volunteers aged 27 to 72 years for 5 consecutive days. The single dose contained 25 mg 7-oxo-DHEA. Serum concentrations of testosterone,estradiol, cortisol, androstenedione, luteinizing hormone (LH), follicle-stimulating hormone (FSH), sex hormone binding globulin (SHBG), total cholesterol, HDL- and LDL-cholesterol, triglycerides, apolipoprotein A-I and B and lipoprotein(a) were measured before the beginning and shortly after the end of the steroid application. After the treatment, we noted the following significant changes: a decline of testosterone and estradiol levels, increase of LH, HDL-cholesterol and apolipoprotein A-I levels. The decrease of total cholesterol levels was of the borderline significance. A slight but significant increase was found in apolipoprotein B and lipoprotein(a). The most expressive was the fall of the atherogenic index. We suggest that the gelcontaining 7-oxo-DHEA might be a suitable drug for improving the composition of the steroid and lipid parameters in elderly men.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 00:50:23