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Titolo:
Cerebral blood flow abnormalities in symptomatic West syndrome: A single photon emission computed tomography study
Autore:
Karagol, U; Deda, G; Uysal, S; Kabakus, N; Ibis, E; Gencoglu, A; Aras, G;
Indirizzi:
Ankara Univ, Fac Med, Dept Pediat, TR-06100 Ankara, Turkey Ankara Univ Ankara Turkey TR-06100 Dept Pediat, TR-06100 Ankara, Turkey Ankara Univ, Fac Med, Dept Nucl Med, TR-06100 Ankara, Turkey Ankara Univ Ankara Turkey TR-06100 ept Nucl Med, TR-06100 Ankara, Turkey
Titolo Testata:
PEDIATRICS INTERNATIONAL
fascicolo: 1, volume: 43, anno: 2001,
pagine: 66 - 70
SICI:
1328-8067(200102)43:1<66:CBFAIS>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFANTILE SPASMS; SPECT; EEG;
Keywords:
children; infantile spasms; single photon emission computed tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Uysal, S Ondokuz Mayis Univ, Sch Med, Dept Pediat Neurol, TR-55000 Samsun,Turkey Ondokuz Mayis Univ Samsun Turkey TR-55000 -55000 Samsun, Turkey
Citazione:
U. Karagol et al., "Cerebral blood flow abnormalities in symptomatic West syndrome: A single photon emission computed tomography study", PEDIATR INT, 43(1), 2001, pp. 66-70

Abstract

Background: Infantile spasm (IS) is an age-dependent epileptic encephalopathy of variable etiology. Although IS is well studied, its pathogenesis is unclear. Infantile spasm is usually considered a generalized epilepsy, but recent studies point to focal cerebral blood flow (CBF) abnormalities. Methods: In six symptomatic IS patients, single photon emission computed tomography (SPECT) with [Tc-99m]-HMPAO, electroencephalography (EEG), magnetic resonance imaging (MRI)/computed tomography (CT) and their correlation were evaluated. Results: Single photon emission computed tomography showed unifocal (regional) cerebral hypoperfusion in two infants, multifocal (diffuse) cerebral hypoperfusion in three infants and normal perfusion in the other infant. Electroencephalograms obtained in near-time of the SPECT studies showed diffuse abnormalities in five infants with hypoperfusion on SPECT. Cranial MRI/CTshowed diffuse and/or localized cerebral lesions in all infants, all of whom had corresponding areas of hypoperfusion on SPECT. In one patient whose spasms were stopped with anticonvulsants, SPECT was normal, in two patientsSPECT showed unifocal lesions, while in another three patients whose spasms were decreased but not stopped, SPECT showed multifocal hypoperfusion. Conclusions: This pilot study may indicate that there are CBF anomalies insymptomatic IS. The degree of CBF may be a predictor of prognosis and multifocal hypoperfusion may be a poor prognostic criteria in IS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 23:12:43