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Titolo:
Effects of albumin infusion therapy on total and unbound bilirubin values in term infants with intensive phototherapy
Autore:
Hosono, S; Ohno, T; Kimoto, H; Nagoshi, R; Shimizu, M; Nozawa, M;
Indirizzi:
Saitama Childrens Med Ctr, Div Neonatol, Iwatuki, Saitama 3398551, Japan Saitama Childrens Med Ctr Iwatuki Saitama Japan 3398551 ma 3398551, Japan
Titolo Testata:
PEDIATRICS INTERNATIONAL
fascicolo: 1, volume: 43, anno: 2001,
pagine: 8 - 11
SICI:
1328-8067(200102)43:1<8:EOAITO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN-STEM RESPONSES; KERNICTERUS;
Keywords:
albumin-priming; hyperbilirubinemia; intensive phototherapy; term infant; unbound bilirubin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Hosono, S Saitama Childrens Med Ctr, Div Neonatol, 2100 Magome, Iwatuki, Saitama 3398551, Japan Saitama Childrens Med Ctr 2100 Magome Iwatuki SaitamaJapan 3398551
Citazione:
S. Hosono et al., "Effects of albumin infusion therapy on total and unbound bilirubin values in term infants with intensive phototherapy", PEDIATR INT, 43(1), 2001, pp. 8-11

Abstract

Background: The purpose of the present study was to evaluate the effect ofintravenous albumin administration on the serum total and unbound bilirubin values in term non-hemolytic hyperbilirubinemic neonates during intensivephototherapy. Methods: Fifty-eight infants (gestational age 39.4+/-1.4 weeks; birth weight 3245+/-435 g) were given phototherapy with similar light energy. Twenty infants (control group) received only phototherapy, while 38 others (albumin-treated group) were also given human albumin at 1 g/kg bodyweight, i.v., during the first 2 h of phototherapy. Results: When comparing changes in total and unbound bilirubin values 0, 2, 6 and 24 h after entering the study between the albumin-treated group andthe control group, there was a significant reduction in the serum unbound bilirubin values at the end of albumin treatment and at 6 and 24 h. However, there was no significant reduction in total serum bilirubin values duringthe study period. In the albumin-treated group, the mean serum unbound bilirubin reduction from the baseline level at the end of albumin treatment and at 6 and 24 h was 0.40+/-0.19, 0.41+/-0.20 and 0.43+/-0.20 mug/dL, respectively. Conclusions: The results suggest that albumin priming may be effective foran immediate reduction in serum unbound bilirubin values, the fraction that is potentially neurotoxic.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:21:02