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Titolo:
Sibling donor cord blood banking for children with sickle cell disease
Autore:
Reed, W; Walters, M; Trachtenberg, E; Smith, R; Lubin, BH;
Indirizzi:
Childrens Hosp Oakland, Res Inst, Sibling Donor Cord Blood Program, Oakland, CA 94609 USA Childrens Hosp Oakland Oakland CA USA 94609 rogram, Oakland, CA 94609 USA
Titolo Testata:
PEDIATRIC PATHOLOGY & MOLECULAR MEDICINE
fascicolo: 2, volume: 20, anno: 2001,
pagine: 167 - 174
SICI:
1522-7952(200103/04)20:2<167:SDCBBF>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; PATIENT; ANEMIA;
Keywords:
cord blood; placental blood; related donor; sickle cell disease; stem cells; transplantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Reed, W Childrens Hosp Oakland, Res Inst, Sibling Donor Cord Blood Program, 747 52nd St, Oakland, CA 94609 USA Childrens Hosp Oakland 747 52nd St Oakland CA USA 94609 94609 USA
Citazione:
W. Reed et al., "Sibling donor cord blood banking for children with sickle cell disease", PEDIAT PATH, 20(2), 2001, pp. 167-174

Abstract

Although hematopoietic stem cell transplantation has curative potential for selected patients with sickle cell disease (SCD), most patients who are eligible for transplantation do not have a suitable donor. Cord blood (CB) from a sibling could provide an alternative stem cell source that, while notas well established as marrow, may offer certain advantages for selected families. These potential advantages include low risk to the infant donor, the possibility that mismatched CB units form sibling donors may be acceptable for transplantation, prompt availability of a stored CB unit for transplant, and decreased risk of clinically significant graft-versus-host disease. When families with SCD (or other transplant-treatable condition) conceivea sibling, no comprehensive research resource exists to assist the family in collecting the new infants CB. With support from the National Heart Lungand Blood Institute, we are developing a noncommercial research-based CB Banking Program specifically for medically indicated sibling donations. In preliminary experience, we have collected CB from 52 SCD families across 19 states. Of these, 2 CB units have thus far been used for transplantation and 9 others are HLA-identical. We conclude that a CB bank focusing on sibling-donations may be feasible, but further study is required to determine whether such a bank can collect CB units of sufficient quantity and quality tosupport controlled trials of sibling CB transplantation. Families with a specific medical need, such as those already caring for a child with SCD, should consider collecting sibling CB as part of comprehensive care if the opportunity becomes available.

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Documento generato il 03/04/20 alle ore 07:30:36