Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effect of fetal hydrocephalus on the distribution patterns of calcium-binding proteins in the human occipital cortex
Autore:
Ulfig, N; Szabo, A; Bohl, J;
Indirizzi:
Univ Rostock, Dept Anat, Neuroembryon Res Lab, D-18055 Rostock, Germany Univ Rostock Rostock Germany D-18055 n Res Lab, D-18055 Rostock, Germany Univ Mainz, Dept Neuropathol, D-6500 Mainz, Germany Univ Mainz Mainz Germany D-6500 Dept Neuropathol, D-6500 Mainz, Germany
Titolo Testata:
PEDIATRIC NEUROSURGERY
fascicolo: 1, volume: 34, anno: 2001,
pagine: 20 - 32
SICI:
1016-2291(200101)34:1<20:EOFHOT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT NERVOUS-SYSTEM; CEREBRAL-CORTEX; HUMAN EMBRYOS; PARVALBUMIN; CALBINDIN; NEURONS; MONKEY; LOCALIZATION; CALRETININ; SUBPLATE;
Keywords:
calretinin; parvalbumin; calbindin; subplate; interneurons; transient structure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Ulfig, N Univ Rostock, Dept Anat, Neuroembryon Res Lab, Gertrudenstr 9, D-18055 Rostock, Germany Univ Rostock Gertrudenstr 9 Rostock Germany D-18055ock, Germany
Citazione:
N. Ulfig et al., "Effect of fetal hydrocephalus on the distribution patterns of calcium-binding proteins in the human occipital cortex", PED NEUROS, 34(1), 2001, pp. 20-32

Abstract

Neuronal pathology in the cerebral cortex (CC) of fetal hydrocephalus brains is quite subtle when applying routine Nissl staining. This study is aimed at investigating alterations of interneurons which can be immunolabelied by antibodies against the calcium-binding proteins calretinin (CR), calbindin (CB) and parvalbumin (PV). The subplate (SP) subjacent to the cortex anlage is included as this transient zone plays a pivotal role in the establishment of cortical connections, Nine occipital lobes from cases of fetal hydrocephalus and 9 controls were categorized according to age: 21-25 weeks ofgestation (group 1) and 32-36 weeks (group 2). No differences in the distribution, number and morphology of CR-immunoreactive (ir) neurons are seen when comparing hydrocephalic with control brains of group 1. In severely altered hydrocephalic brains of group 2, the distribution and number of CR-, PV- and CB-ir nerve cells are not altered; however, they appear shrunken andprocesses are less immunolabelled. In extremely altered tissue PV-, CB-ir neurons cannot be detected, whereas the number of CR-ir somata is not reduced. The data indicate that subpopulations of interneurons of the CC may be differentially damaged. The alterations observed in the SP may implicate a possible impairment of transient neuronal circuitries that are essential for the development of cortical connections. On the whole, these neuronal alterations may account for residual deficits observed after shunting. Copyright (C) 2001 S.Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:11:48