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Titolo:
Control of glomerular capillary development by growth factor/receptor kinases
Autore:
Robert, B; Abrahamson, DR;
Indirizzi:
Univ Kansas, Med Ctr, Dept Anat & Cell Biol, Kansas City, KS 66160 USA Univ Kansas Kansas City KS USA 66160 Cell Biol, Kansas City, KS 66160 USA
Titolo Testata:
PEDIATRIC NEPHROLOGY
fascicolo: 3, volume: 16, anno: 2001,
pagine: 294 - 301
SICI:
0931-041X(200103)16:3<294:COGCDB>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR TYROSINE KINASE; EMBRYONIC ANGIOGENESIS; KIDNEY DEVELOPMENT; ENDOTHELIAL-CELLS; VESSEL FORMATION; PDGF-RECEPTOR; EPH RECEPTORS; MICE LACKING; FACTOR VEGF; IN-VIVO;
Keywords:
angiogenesis; glomerulus; receptor tyrosine kinases; vasculogenesis; vascular endothelial growth factor;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Abrahamson, DR Univ Kansas, Med Ctr, Dept Anat & Cell Biol, 3901 Rainbow Blvd, Kansas City, KS 66160 USA Univ Kansas 3901 Rainbow Blvd Kansas City KSUSA 66160 USA
Citazione:
B. Robert e D.R. Abrahamson, "Control of glomerular capillary development by growth factor/receptor kinases", PED NEPHROL, 16(3), 2001, pp. 294-301

Abstract

Multiple signaling processes, including cell-matrix and cell-cell interactions, and growth factor/receptor binding, are crucially important for guiding blood vessel formation. Here we summarize current data, much of which has been obtained recently from gene targeting in mice, on the roles played by the growth factor ligand/receptor tyrosine kinase systems represented by:vascular endothelial growth factor (VEGF) and its receptors; Eph/Ephrins; Tie1, Tie2 and angiopoietins; and platelet-derived growth factor (PDGF) in glomerular capillary development. A fundamental understanding of glomerularendothelial growth and differentiation during organogenesis may provide clues for stimulating glomerular repair after toxic injury or ischemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 07:04:40