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Titolo:
Blastic natural killer cell lymphoma arising from the mediastinum with terminal deoxynucleotidyl transferase expression
Autore:
Isobe, K; Tamaru, J; Nakamura, S; Itami, J; Aruga, T; Uno, T; Yasuda, S; Mikata, A; Ito, H;
Indirizzi:
Chiba Univ, Sch Med, Dept Radiol, Chuo Ku, Chiba 2608670, Japan Chiba Univ Chiba Japan 2608670 ept Radiol, Chuo Ku, Chiba 2608670, Japan Saitama Med Sch, Saitama Med Ctr, Dept Pathol, Kawagoe, Saitama, Japan Saitama Med Sch Kawagoe Saitama Japan pt Pathol, Kawagoe, Saitama, Japan Aichi Canc Ctr Hosp, Dept Pathol, Nagoya, Aichi 464, Japan Aichi Canc Ctr Hosp Nagoya Aichi Japan 464 thol, Nagoya, Aichi 464, Japan Aichi Canc Ctr Hosp, Clin Labs, Nagoya, Aichi 464, Japan Aichi Canc Ctr Hosp Nagoya Aichi Japan 464 Labs, Nagoya, Aichi 464, Japan Int Med Ctr, Dept Radiat Oncol, Tokyo, Japan Int Med Ctr Tokyo JapanInt Med Ctr, Dept Radiat Oncol, Tokyo, Japan Narita Red Cross Hosp, Div Pathol, Narita, Japan Narita Red Cross Hosp Narita Japan ross Hosp, Div Pathol, Narita, Japan
Titolo Testata:
PATHOLOGY INTERNATIONAL
fascicolo: 1, volume: 51, anno: 2001,
pagine: 55 - 59
SICI:
1320-5463(200101)51:1<55:BNKCLA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPSTEIN-BARR-VIRUS; ACUTE LYMPHOBLASTIC-LEUKEMIA; LOWER RESPIRATORY-TRACT; NK-CELL; IN-VITRO; CD56; ASSOCIATION; PATIENT; LINEAGE; MALIGNANCIES;
Keywords:
blastic natural killer cell lymphoma; terminal deoxynucleotidyl transferase; Epstein-Barr virus; mediastinum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Ito, H Chiba Univ, Sch Med, Dept Radiol, Chuo Ku, 1-8-1 Inohana, Chiba 2608670, Japan Chiba Univ 1-8-1 Inohana Chiba Japan 2608670 Chiba 2608670, Japan
Citazione:
K. Isobe et al., "Blastic natural killer cell lymphoma arising from the mediastinum with terminal deoxynucleotidyl transferase expression", PATHOL INT, 51(1), 2001, pp. 55-59

Abstract

Blastic natural killer (NK) cell lymphoma/leukemia is a relatively rare NKcell malignancy. We report the second case of blastic NK cell lymphoma arising from the mediastinum with an aggressive clinical course. The patient was a 63-year-old Japanese man with an anterior mediastinum tumor. The biopsy specimen showed diffuse proliferation of tumor cells with frequent mitotic figures and apoptotic bodies. Both angiocentric features and small foci of coagulative necrosis were found in this section. The tumor cells had medium to large nuclei with a fine chromatin pattern, inconspicuous nucleoli and scanty cytoplasm. The nuclear contour was oval to moderately irregular, showing slight pleomorphism as compared with typical lymphoblastic lymphoma. The tumor cells were positive for CD2, CD56 and terminal deoxynucleotidyl transferase, but negative for other T-cell antigens, B-cell antigens and myeloid markers. In situ hybridization for Epstein-Barr virus encoded small ribonucleic acid 1 was negative.

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Documento generato il 05/04/20 alle ore 09:44:29