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Titolo:
Overexpression of p53 protein and MDM2 in papillary carcinomas of the thyroid: Correlations with clinicopathologic features
Autore:
Horie, S; Maeta, H; Endo, K; Ueta, T; Takashima, K; Terada, T;
Indirizzi:
Tottori Univ, Fac Med, Dept Pathol 2, Yonago, Tottori 6838503, Japan Tottori Univ Yonago Tottori Japan 6838503 Yonago, Tottori 6838503, Japan
Titolo Testata:
PATHOLOGY INTERNATIONAL
fascicolo: 1, volume: 51, anno: 2001,
pagine: 11 - 15
SICI:
1320-5463(200101)51:1<11:OOPPAM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGNOSTIC FACTORS; GENE; EXPRESSION; MUTATIONS; POPULATION; SURVIVAL; CANCER; GLAND;
Keywords:
immunohistochemistry; MDM2; neoplasms; p53; papillary carcinoma of the thyroid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Terada, T Tottori Univ, Fac Med, Dept Pathol 2, 86 Nishi Cho, Yonago, Tottori 6838503, Japan Tottori Univ 86 Nishi Cho Yonago Tottori Japan 6838503 03, Japan
Citazione:
S. Horie et al., "Overexpression of p53 protein and MDM2 in papillary carcinomas of the thyroid: Correlations with clinicopathologic features", PATHOL INT, 51(1), 2001, pp. 11-15

Abstract

Expression of p53 protein and MDM2 was evaluated in paraffin-embedded tissue from 78 patients with papillary carcinomas of the thyroid (PCT), in order to elucidate the relationship between them and their correlations with some clinicopathologic features implicated in tumor progression. These proteins were expressed in nuclei of tumor cells, but not in non-tumor cells. Staining was defined as positive when 10% or more of tumor cells expressed these proteins. The number of cases positive for p53 protein was 21/78 (27%), and that positive for MDM2 was 26/78 (33%). Co-overexpression of p53 protein and MDM2 was observed in 12/78 cases (15%). A significant positive relationship was found between them (P < 0.01); p53-positive cases tended to be also positive for MDM2 and vice versa. Statistical analysis revealed that overexpression of p53 protein significantly correlated with large tumor size (P = 0.0271) and the presence of capsular invasion (P = 0.04). There were significant positive correlations between tumor size and intrathyroidal invasion and between tumor size and capsular invasion in PCT, suggesting that p53 protein overexpression is associated only with tumor progression (tumor size). However, we could not find any significant correlations between MDM2expression and clinicopathologic features. Our findings suggest that overexpression of p53 protein and MDM2 in papillary carcinoma of the thyroid is associated with the progression of the tumors, and that p53 may be a markerof the progression of PCT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 00:17:55