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Titolo:
Adrenocorticotropin-independent unilateral adrenocortical hyperplasia withCushing's syndrome: Immunohistochemical studies of steroidogenic enzymes, ultrastructural examination and a review of the literature
Autore:
Takamura, T; Nagai, Y; Taniguchi, M; Yamashita, H; Nakamura, S; Ikeda, T; Kobayashi, KI; Suzuki, T; Sasano, H;
Indirizzi:
Kanazawa Univ, Sch Med, Dept Internal Med 1, Kanazawa, Ishikawa 9208641, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208641 wa, Ishikawa 9208641, Japan Tsuruga Municipal Hosp, Fukui, Japan Tsuruga Municipal Hosp Fukui JapanTsuruga Municipal Hosp, Fukui, Japan Tohoku Univ, Sch Med, Dept Pathol, Sendai, Miyagi 980, Japan Tohoku Univ Sendai Miyagi Japan 980 ept Pathol, Sendai, Miyagi 980, Japan
Titolo Testata:
PATHOLOGY INTERNATIONAL
fascicolo: 2, volume: 51, anno: 2001,
pagine: 118 - 122
SICI:
1320-5463(200102)51:2<118:AUAHW>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
NODULAR HYPERPLASIA; ADRENAL-CORTEX; CYTOCHROME-P-450; GLAND;
Keywords:
adrenal hyperplasia; Cushing's syndrome; immunohistochemistry; steroidogenic enzyme;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Takamura, T Kanazawa Univ, Sch Med, Dept Internal Med 1, 13-1 Takara Machi, Kanazawa, Ishikawa 9208641, Japan Kanazawa Univ 13-1 Takara Machi Kanazawa Ishikawa Japan 9208641
Citazione:
T. Takamura et al., "Adrenocorticotropin-independent unilateral adrenocortical hyperplasia withCushing's syndrome: Immunohistochemical studies of steroidogenic enzymes, ultrastructural examination and a review of the literature", PATHOL INT, 51(2), 2001, pp. 118-122

Abstract

A 60-year-old woman presented with a history of palpitations, headaches and severe hypertension, which was resistant to hypotensive agents. She had a2-year history of obesity and a moon face. Her plasma adrenocorticotropic hormone level was below the limits of detection and did not respond to corticotropin-releasing hormone. Urinary-free cortisol was elevated and the circadian rhythm of serum cortisol level had completely disappeared. Imaging analysis demonstrated a unilaterally functioning mass in the left adrenal gland. Serum cortisol level in the left adrenal vein was elevated. The resected adrenal mass measured 4 x 3.5 x 2.5 cm, and ranged from yellow to tan incolor. The adrenal cortex adjacent to the nodule did not demonstrate cortical atrophy. The mass was well circumscribed but not encapsulated, and consisted of multiple cortical nodules. These nodules were composed predominantly of clear cortical cells, and partly of compact cortical cells. Immunoreactivity of steroidogenic enzymes including cholesterol side-chain-cleavage P450, 3 beta -hydroxysteroid dehydrogenase, 21-hydroxylase cytochrome P450,11 beta -hydroxylase cytochrome P450 and 17 alpha -hydroxylase cytochrome P450 was marked in cortical nodules, but minimal in non-nodular cortex. Ultrastructural examination of nodular cortical cells also demonstrated well-developed mitochondria and smooth endoplasmic reticulum, consistent with elevated steroidogenesis in these cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 13:26:32