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Titolo:
Genetic analysis of pancreatic duct hyperplasia in Otsuka Long-Evans Tokushima Fatty rats: Possible association with a region on rat chromosome 14 that includes the disrupted cholecystokinin-A receptor gene
Autore:
Kanemoto, N; Kondo, M; Iwanaga, T; Hishigaki, H; Ono, T; Mizoguchi-Miyakita, A; Oga, K; Tsuji, A; Okuno, S; Watanabe, TK; Nose, M; Tanigami, A;
Indirizzi:
Otsuka Pharmaceut Co Ltd, Otsuka GEN Res Inst, Kawauchi, Tokushima 7710192, Japan Otsuka Pharmaceut Co Ltd Kawauchi Tokushima Japan 7710192 7710192, Japan Ehime Univ, Sch Med, Dept Pathol, Matsuyama, Ehime, Japan Ehime Univ Matsuyama Ehime Japan d, Dept Pathol, Matsuyama, Ehime, Japan
Titolo Testata:
PATHOLOGY INTERNATIONAL
fascicolo: 3, volume: 51, anno: 2001,
pagine: 133 - 139
SICI:
1320-5463(200103)51:3<133:GAOPDH>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; CANCER CELL-LINES; BN X OLETF; GROWTH; LINKAGE; MODEL; ADENOCARCINOMA; DISSECTION; CARCINOGENESIS; AZASERINE;
Keywords:
Cckar; Otsuka Long-Evans Tokushima Fatty rat; pancreatic duct hyperplasia; rat chromosome 14;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Tanigami, A Otsuka Pharmaceut Co Ltd, Otsuka GEN Res Inst, 463-10 Kagasuno, Kawauchi, Tokushima 7710192, Japan Otsuka Pharmaceut Co Ltd 463-10 Kagasuno Kawauchi Tokushima Japan 7710192
Citazione:
N. Kanemoto et al., "Genetic analysis of pancreatic duct hyperplasia in Otsuka Long-Evans Tokushima Fatty rats: Possible association with a region on rat chromosome 14 that includes the disrupted cholecystokinin-A receptor gene", PATHOL INT, 51(3), 2001, pp. 133-139

Abstract

An Otsuka Long-Evans Tokushima Fatty (OLETF) strain of rat spontaneously developed hyperglycemia, hyperinsulinemia, insulin resistance and mild obesity, which had been studied as animal model for type II diabetes mellitus (T2DM). Recently, we observed that this strain coincidentally developed atypical hyperplasia of the choledocho-pancreatic ductal epithelium with a complete incidence. In an effort to locate genes responsible for this hyperplasia, we prepared 288 backcross progeny from a mating between OLETF rats and BN rats (which do not develop hyperplasia), and performed a genome-wide scanusing 207 polymorphic genetic markers. We observed a prominent associationof hyperplasia with a region involving a marker locus D14Mit4 (P = 0.00020, Fisher's exact test) and Cckar (the cholecystokinin-A receptor gene; P = 0.00025, Fisher's exact test) which is known to be disrupted in an OLETF strain. Our findings indicated that epithelial hyperplasia of the choledocho-pancreatic duct is associated with a region on rat chromosome 14 around theCckar gene in an additive fashion with another two susceptible loci, each on chromosome 9 and 7. This implied the possibility that Cckar deficiency could result in a predisposition towards pancreatic duct hyperplasia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/06/20 alle ore 05:51:52