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Titolo:
Neonatal iron potentiates adult MPTP-induced neurodegenerative and functional deficits
Autore:
Fredriksson, A; Schroder, N; Eriksson, P; Izquierdo, I; Archer, T;
Indirizzi:
Univ Uppsala, Univ Hosp, Psychiat Ulleraker, Dept Neurosci, SE-75017 Uppsala, Sweden Univ Uppsala Uppsala Sweden SE-75017 Neurosci, SE-75017 Uppsala, Sweden UFRGS, Dept Bioquim, Porto Alegre, RS, Brazil UFRGS Porto Alegre RS Brazil RGS, Dept Bioquim, Porto Alegre, RS, Brazil Univ Uppsala, Dept Environm Toxicol, SE-75017 Uppsala, Sweden Univ Uppsala Uppsala Sweden SE-75017 m Toxicol, SE-75017 Uppsala, Sweden Univ Gothenburg, Dept Psychol, S-40020 Gothenburg, Sweden Univ GothenburgGothenburg Sweden S-40020 ol, S-40020 Gothenburg, Sweden
Titolo Testata:
PARKINSONISM & RELATED DISORDERS
fascicolo: 2, volume: 7, anno: 2001,
pagine: 97 - 105
SICI:
1353-8020(200104)7:2<97:NIPAMN>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRIATAL DOPAMINERGIC MARKERS; BRAIN MUSCARINIC RECEPTORS; RAT SUBSTANTIA-NIGRA; PARKINSONS-DISEASE; TREATED MICE; L-DOPA; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MPTP; NEUROBEHAVIORAL DYSFUNCTIONS; SYNERGISTIC INTERACTIONS; BEHAVIORAL-CHANGES;
Keywords:
iron-overload; neonatal; MPTP; spontaneous motor behaviour; habituation; dopamine; metabolites; total iron; basal ganglia; frontal cortex; C57B1/6 mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Fredriksson, A Univ Uppsala, Univ Hosp, Psychiat Ulleraker, Dept Neurosci,SE-75017 Uppsala, Sweden Univ Uppsala Uppsala Sweden SE-75017 5017 Uppsala, Sweden
Citazione:
A. Fredriksson et al., "Neonatal iron potentiates adult MPTP-induced neurodegenerative and functional deficits", PARKINS R D, 7(2), 2001, pp. 97-105

Abstract

The interactive effects of neonatal iron and adult MPTP treatment groups of C57 B1/6 mice were studied through adminustration of iron (Fe2+) 7.5 mg/kg b.w., p.o. or vehicle (saline) on days 10-12 post partum, followed at 3 months of age by administration of either MPTP (2 x 20 or 2 x 40 mg/kg, s.c.) or saline. Neonatal iron administration to mice-induced hypoactivity during the first 20-min period of testing and hyperactivity during the 3rd and final 20-min period for all three parameters of motor activity tested at 4 months of age. MPTP treatment caused a dose-related hypokinesia throughout the 3 x 20-min test periods; in the mice that received both neonatal iron and MPTP severe deficits of motor activity (akinesia) were obtained. Iron treatment impaired the ability of mice to habituate to the novel testing environment and later administration of MPTP potentiated the impairment markedly. Neurochemical analyses of striatal and frontal cortical dopamine (DA) and DA metabolites demonstrated that the depletions were potentiated under conditions of combined neonatal iron and adult MPTP. The analysis of total iron content (mug/g) in brain regions indicated notably elevated levels in the basal ganglia, but not in the frontal cortex, of mice administered Fe2+. Iron-overload combined with MPTP treatment induced functional and neurochemical deficits with interactive consequences beyond a mere additive effect that may have implications for the neurodegenerative process in parkinsonism. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:54:03