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Titolo:
The parkin gene S/N167 polymorphism in Australian Parkinson's disease patients and controls
Autore:
Mellick, GD; Buchanan, DD; Hattori, N; Brookes, AJ; Mizuno, Y; Le Couteur, DG; Silburn, PA;
Indirizzi:
Univ Queensland, Princess Alexandra Hosp, Dept Med, Woolloongabba, Qld, Australia Univ Queensland Woolloongabba Qld Australia oolloongabba, Qld, Australia Juntendo Univ, Dept Neurol, Tokyo 113, Japan Juntendo Univ Tokyo Japan 113 ntendo Univ, Dept Neurol, Tokyo 113, Japan Karolinska Inst, Ctr Genom Res, S-10401 Stockholm, Sweden Karolinska InstStockholm Sweden S-10401 Res, S-10401 Stockholm, Sweden Univ Sydney, Canberra Hosp, Canberra Clin Sch, Canberra, ACT, Australia Univ Sydney Canberra ACT Australia ra Clin Sch, Canberra, ACT, Australia Princess Alexandra Hosp, Dept Neurol, Woolloongabba, Qld 4102, Australia Princess Alexandra Hosp Woolloongabba Qld Australia 4102 4102, Australia
Titolo Testata:
PARKINSONISM & RELATED DISORDERS
fascicolo: 2, volume: 7, anno: 2001,
pagine: 89 - 91
SICI:
1353-8020(200104)7:2<89:TPGSPI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECESSIVE JUVENILE PARKINSONISM; HOMOZYGOUS DELETIONS; MUTATIONS; JAPANESE; FAMILIES; DNA;
Keywords:
parkin gene; polymorphism; A allele;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Mellick, GD Univ Queensland, Princess Alexandra Hosp, Dept Med, Woolloongabba, Qld, Australia Univ Queensland Woolloongabba Qld Australia , Qld, Australia
Citazione:
G.D. Mellick et al., "The parkin gene S/N167 polymorphism in Australian Parkinson's disease patients and controls", PARKINS R D, 7(2), 2001, pp. 89-91

Abstract

This study determined the frequencies of a G-to-A transition (S/N167) polymorphism in exon 4 of the parkin gene in Australian Parkinson's disease patients and control subjects. The genotype of each subject was determined using the polymerase chain reaction and restriction-fragment-length-polymorphism analysis. Overall, the A allele was significantly less common in the Parkinson's disease group (1.7%) compared with the control group (3.8%, OR = 0.43, 95% CI = 0.19-1.00, P < 0.05), although the frequency in the young onset Parkinson's disease group (6.6%) was not significantly different to controls. The A allele is less common in Australian Caucasian subjects comparedto Japanese Parkinson's disease patients and appears to be under-represented in older-onset Parkinson's disease. <(c)> 2001 Elsevier Science Ltd. Allrights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 17:18:42