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Titolo:
Pattern of distribution and prognostic value of angiogenesis in pancreaticduct carcinoma: A semiquantitative immunohistochemical study of 45 patients
Autore:
Linder, S; Blasjo, M; von Rosen, A; Parrado, C; Falkmer, UG; Falkmer, S;
Indirizzi:
Soder Sjukhuset, Dept Surg, S-11883 Stockholm, Sweden Soder Sjukhuset Stockholm Sweden S-11883 Surg, S-11883 Stockholm, Sweden Soder Sjukhuset, Dept Pathol, S-11883 Stockholm, Sweden Soder Sjukhuset Stockholm Sweden S-11883 thol, S-11883 Stockholm, Sweden Karolinska Hosp, Karolinska Inst, Fac Med, Dept Surg, S-10401 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-10401 Surg, S-10401 Stockholm, Sweden Univ Malaga, Fac Med, Dept Histol, E-29071 Malaga, Spain Univ Malaga Malaga Spain E-29071 Med, Dept Histol, E-29071 Malaga, Spain Norwegian Univ Sci & Technol, Fac Med, Dept Oncol, N-7034 Trondheim, Norway Norwegian Univ Sci & Technol Trondheim Norway N-7034 4 Trondheim, Norway Norwegian Univ Sci & Technol, Fac Med, Dept Lab Med, Div Morphol & Pathol,N-7034 Trondheim, Norway Norwegian Univ Sci & Technol Trondheim Norway N-7034 4 Trondheim, Norway
Titolo Testata:
PANCREAS
fascicolo: 3, volume: 22, anno: 2001,
pagine: 240 - 247
SICI:
0885-3177(200104)22:3<240:PODAPV>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
INVASIVE BREAST-CARCINOMA; ENDOTHELIAL-CELL PROLIFERATION; TUMOR ANGIOGENESIS; MICROVESSEL DENSITY; SOLID TUMORS; DNA-PLOIDY; CANCER; EXPRESSION; INDICATOR; ADENOCARCINOMA;
Keywords:
pancreatic duct adenocarcinoma; angiogenesis; Proliferation Index; expression of p53 protein; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Linder, S Soder Sjukhuset, Dept Surg, S-11883 Stockholm, Sweden Soder Sjukhuset Stockholm Sweden S-11883 883 Stockholm, Sweden
Citazione:
S. Linder et al., "Pattern of distribution and prognostic value of angiogenesis in pancreaticduct carcinoma: A semiquantitative immunohistochemical study of 45 patients", PANCREAS, 22(3), 2001, pp. 240-247

Abstract

In specimens obtained from resected pancreata, the intratumoral microvessel density (IMD), the proliferation rate of the neoplastic parenchymal cells, and their p53 protein expression were assessed. The sources of errors were great in the measurements of the IMD. This statement can be illustrated by the finding that when the IMD was calculated by manual counting in five areas of intense neovascularization (hot spot regions), using x200 and x400 magnifications, the numbers of microvessels per square millimeter were 65 +/- 23 and 106 +/- 8, respectively, which reflects a significant difference. Two pat terns of microvessel distribution could be identified: one with hot spots only in the stroma(n = 19) and one in which the hot spots were located in areas of neoplastic parenchyma (including its stroma) (n = 26). The IMD was significantly greater in the latter group. Then was no general correlation of neoplastic disease with the IMD. However, when a scoring system was used to assess the angiogenesis, hot spots in areas of neoplastic parenchyma were associated with a greater proliferation rate of the tumor cells,and with a short length of survival of the patients from their neoplastic disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:48:38