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Titolo:
Mismatch between lactate and the apparent diffusion coefficient of water in progressive focal ischemia
Autore:
Takegami, T; Ebisu, T; Bito, Y; Hirata, S; Yamamoto, Y; Tanaka, C; Naruse, S; Mineura, K;
Indirizzi:
Kyoto Prefectural Univ Med, Dept Neurosurg, Kyoto 602, Japan Kyoto Prefectural Univ Med Kyoto Japan 602 t Neurosurg, Kyoto 602, Japan Meiji Univ Oriental Med, Dept Neurosurg, Kyoto, Japan Meiji Univ Oriental Med Kyoto Japan l Med, Dept Neurosurg, Kyoto, Japan Meiji Univ Oriental Med, Med MR Ctr, Kyoto, Japan Meiji Univ Oriental MedKyoto Japan ental Med, Med MR Ctr, Kyoto, Japan Hitachi Ltd, Cent Res Lab, Med Syst Res Dept, Tokyo, Japan Hitachi Ltd Tokyo Japan , Cent Res Lab, Med Syst Res Dept, Tokyo, Japan Kyoto Prefectural Univ Med, Dept Radiol, Kyoto, Japan Kyoto Prefectural Univ Med Kyoto Japan v Med, Dept Radiol, Kyoto, Japan
Titolo Testata:
NMR IN BIOMEDICINE
fascicolo: 1, volume: 14, anno: 2001,
pagine: 5 - 11
SICI:
0952-3480(200102)14:1<5:MBLATA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; MAGNETIC-RESONANCE SPECTROSCOPY; INTERNAL CAROTID-ARTERY; PROTON MR SPECTROSCOPY; INTRACRANIAL HYPERTENSION; ACUTE STROKE; CAT BRAIN; ENERGY-METABOLISM; GLOBAL-ISCHEMIA; RAT;
Keywords:
diffusion-weighted imaging; echo planar spectroscopic imaging; focal ischemia; lactate; apparent diffusion coefficient; penumbra;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Ebisu, T Meiji Univ Oriental med, Dept Neurosurg, Hiyoshi, Kyoto 6290392, Japan Meiji Univ Oriental med Hiyoshi Kyoto Japan 6290392 90392, Japan
Citazione:
T. Takegami et al., "Mismatch between lactate and the apparent diffusion coefficient of water in progressive focal ischemia", NMR BIOMED, 14(1), 2001, pp. 5-11

Abstract

In this study, we examined mismatch in the area indicated by the normal apparent diffusion coefficient (ADC) of water and increased lactate in the early stage of focal cerebral ischemia. Five rats were subjected to permanentmiddle cerebral artery (MCA) occlusion. Diffusion-weighted echo planar imaging (DWEPI) and proton echo planar spectroscopic imaging (EPSI) were performed from 20 to 170 min after MCA occlusion, and lactate and N-acetyl asparate images were obtained by EPSI. Postmortem histological analysis was alsoperformed. The areas of increased lactate and normal ADC were observed in the surrounding border zone of ischemia at approximately 20 min after MCA occlusion. This initial lactate in the border zone was significantly higher than that in the normal area, but lower than that in the ischemic core, which showed a reduction of ADC. However, this area was progressively involvedin the ischemic core at 170 min without any treatment. The lactate-ADC mismatch in the initial period of ischemia may offer unique diagnostic information for ischemic tissue at high risk, followed by progressive involvement in the ischemic core without treatment. Considering that the accumulation of initial lactate in this area was not excessive, our findings may suggest that the lactate-ADC mismatch in the early period of ischemia indicates potentially salvageable tissue at high risk, requiring aggressive treatment. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:00:56